Results 111 to 120 of about 13,952 (268)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Two New Theories for the Current Charge Relativity and the Electric Origin of the Magnetic Force Between Two Filamentary Current Elements

IEEE Access, 2016
This paper presents two new theories and a new current representation to explain the magnetic force between two filamentary current elements as a result of electric force interactions between current charges. The first theory states that a current has an
Waseem Ghassan Tahseen Shadid
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

SÜNNETi YORUMLAMADA ÖZNELLiK SORUNU: UBEYDULLAH B. EL-HASEN ÖRNEGi

Fırat Üniversitesi İlahiyat Fakültesi Dergisi, 2006
Gerçek nedir? Gerçeğin bilgisine ulaşılabilir mi? Gerçek muayyen ve tek midir? Bu bilgi ne ölçüde kavranabilir? Soruları, ilk çağ felsefesinden beri tartışılmıştır.
Hüseyin Hansu
doaj  

Relative projectivity and relative endotrivial modules

Journal of Algebra, 2011
Let \(G\) be a finite group, \(k\) an algebraically closed field of characteristic \(p>0\) and \(V\) a finitely generated \(kG\)-module. A finitely generated \(kG\)-module \(M\) is called relatively \(V\)-projective if \(M\) is a direct summand of \(V\otimes N\) for some finitely generated \(kG\)-module \(N\).
openaire   +2 more sources

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Concept of quantum wave gravitation in the Euclidean model of space and time

Frontiers in Physics
The Euclidean Model of Space and Time (EMST) was created as an alternative to the Special Theory of Relativity (STR) and the associated concept of spacetime. This model subsequently proved successful in describing elementary particles of matter and their
Radovan Machotka
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source