Results 141 to 150 of about 76,072 (261)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
The Comparative Study of Time in Mulla Sadra’s Perspective and Theory of Relativity in Physics [PDF]
حکمت صدرایی, 2015 The purpose of this essay is studying of time’s nature in MullaSadra’s perspective and current relativistic theories, includingspecial and general relativity, and proceeding similarities and differences between them.
valiollah khoshtinat +1 more
doaj
Michelson, FitzGerald and Lorentz: the origins of relativity revisited [PDF]
, 2003 It is argued that an unheralded moment marking the beginnings of relativity theory occurred in 1889, when G. F. FitzGerald, no doubt with the puzzling 1887 Michelson-Morley experiment fresh in mind, wrote to Heaviside about the possible effects of motion
Harvey R Brown, Brown, Harvey R.
core
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Change in Hamiltonian General Relativity from the Lack of a Time-like Killing Vector Field [PDF]
, 2013 In General Relativity in Hamiltonian form, change has seemed to be missing, defined only asymptotically, or otherwise obscured at best, because the Hamiltonian is a sum of first-class constraints and a boundary term and thus supposedly generates gauge ...
Pitts, J. Brian, J. Brian Pitts
core
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
MONOLOGUE AND DIALOGUE IN ANTI-CLERICAL CRITICISM AND IN RELIGIOUS PRACTICE
Вестник Кемеровского государственного университета, 2013 The problems of monologue and dialogue as communicative scenarios of religious activity implementation in the modern secular society are investigated in the paper. Dialogue and monologue prospects in religious associations' relations with one another and
E. O. Gavrilov
doaj
Alternative conventions and geometry for special relativity [PDF]
, 2004 This paper argues that Einstein’s conventionalist definition of time is sufficient for, but not necessary to the geometric modelling of Special Relativity.
Crabbe, A
core
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Twin Paradox and the Logical Foundation of Relativity Theory [PDF]
, 2005 We study the foundation of space-time theory in the framework of first-order logic (FOL). Since the foundation of mathematics has been successfully carried through (via set theory) in FOL, it is not entirely impossible to do the same for space-time ...
István, Németi +2 more
core