Results 211 to 220 of about 86,860 (314)

Exact non-static cylindrical solutions of Einstein's field equations with imperfect fluids. [PDF]

PLoS One
Hussain T, Farhan M, Mostafa H, Shezan SA, Amin N, Alsisi RH, Ahmad N.   +6 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Master field equations for spherically symmetric gravitational fields beyond general relativity. [PDF]

Nat Commun
Carballo-Rubio R.
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Immune Trajectories After Switch to Long-Acting Cabotegravir Plus Rilpivirine in the RELATIVITY Cohort. [PDF]

Open Forum Infect Dis
Troya J, Cabello-Clotet N, Bernardino JI, Galindo MJ, Martínez RM, Martín J, Alemán MR, Torralba M, Fanjul F, Fariñas MC, Rodríguez A, Crusells MJ, Calzado S, Pérez-Serrano J, Hidalgo-Tenorio C, Morano LE, Vinuesa D, Bernal-Morell E, Poquet-Catalá I, Pernas-Pardavila H, Tiraboschi J, Corps D, Vivancos MJ, Buzón-Martín L, RELATIVITY Cohort, RELATIVITY Cohort .   +25 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

The principles of systems biology. [PDF]

Exp Physiol
Noble D, Bourret R.
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Special relativity : a heuristic approach /

Includes bibliographical references and index.Online resource; title from PDF title page (ScienceDirect, viewed May 19, 2017).Front Cover; Special Relativity; Copyright; Contents; Preface; List of Symbols, Phrases, and Acronyms; Note to the Reader; 1 ...
Hassani, Sadri,author.
core  

Promoting the Mathematization of Physics: Hermann Minkowski's Draft Presentations of His 1908 "Grundgleichungen" Paper. [PDF]

Ber Wiss
Sauer T.
europepmc   +1 more source