Results 101 to 110 of about 7,841 (218)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Subalgebras of Golod-Shafarevich algebras [PDF]
, 2006 In 1964, Golod and Shafarevich found a sufficient condition for an algebra presented by generators and relators to be infinite dimensional. This condition gives rise to an analogous condition for a pro-p group to be infinite.
Voden, Thomas B.
core
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
, 2023 Deutsche Forschungsgemeinschaft http://dx.doi.org/10.13039 ...
Zaina, Ambreen +2 more
openaire +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
The grammaticization of directional verbs in Oceanic languages
, 2012 In Oceanic languages we often find directional elements which were originally directional verbs in serial verb constructions. The various grammaticization paths that have led to the modern constructions are described in this article.
Ross, Malcolm
core
, 2013 Let Mn,m be a free metabelian nilpotent Lie algebra of rank n and nilpotency class m - 1. We show that Mn,m admits a minimal presentation whose set of defining relators is the set of all basic commutators of length m.
Gök G.K., KAYA GÖK, GÜLİSTAN
core +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Forcing was first introduced by Paul J. Cohen in his work on the independence of the Continuum Hypothesis. Other formulations of forcing appeared using Model Theory, Boolean-valued Models, and Topos Theory. There is a folkloric claim that these three approaches are equivalent, at least at the level of their mathematical content.
Smykalla, Michel Viana +1 more
openaire +2 more sources