Results 141 to 150 of about 4,040 (274)

THE GROUP OF A LINK IN A 3 - MANIFOLD

, 1978
Não disponívelIn this work we get the presentation of the group of a link in R3 with good projection, the relators being obtained locally in à neighbourhood of the link\'s crossing points, a fact that minimizes the number of letters of these relators ...
Pergher, Pedro Luiz Queiroz
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

The grammaticization of directional verbs in Oceanic languages

, 2012
In Oceanic languages we often find directional elements which were originally directional verbs in serial verb constructions. The various grammaticization paths that have led to the modern constructions are described in this article.
Ross, Malcolm
core  

How did investigations into spontaneous human combustion influence alcohol medicine? An examination of the medical and literary discussions that brought the two together. [PDF]

Addiction
Smith I, Lock P.
europepmc   +1 more source

Ontology-based specification, identification and analysis of perioperative risks. [PDF]

J Biomed Semantics, 2017
Uciteli A, Neumann J, Tahar K, Saleh K, Stucke S, Faulbrück-Röhr S, Kaeding A, Specht M, Schmidt T, Neumuth T, Besting A, Stegemann D, Portheine F, Herre H.   +13 more
europepmc   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Dexamethasone induced Dectin-1 activation enhances NLRP3 inflammasome activation. [PDF]

Front Immunol
Koerber RM, Oberbeck S, Kotthoff P, Daecke SN, Brossart P, Held SAE.   +5 more
europepmc   +1 more source

OntoStudyEdit: a new approach for ontology-based representation and management of metadata in clinical and epidemiological research. [PDF]

J Biomed Semantics, 2015
Uciteli A, Herre H.
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

The adjunction problem over torsion-free groups. [PDF]

Proc Natl Acad Sci U S A, 2005
Forester M, Rourke C.
europepmc   +1 more source