Advanced Science, EarlyView.This work develops dynamically softening polyacrylamide hydrogels for time‐resolved imaging during continuous mechanical transitions. The study revealed that mechanotransduction is biphasic; YAP/TAZ inactivation is driven by early loss of the nucleocytoskeletal continuum connecting subnuclear adhesions, F‐actin, and the nuclear envelope, coupled with ...
Alessandro Gandin +12 more
wiley +1 more source
The effect of progressive muscle relaxation therapy on diabetes distress & anxiety among people with type 2 diabetes. [PDF]
Indian J Med ResArunraj M +3 more
europepmc +1 more source
Advanced Science, EarlyView.Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley +1 more source
Guided imagery relaxation therapy on preoperative anxiety: why did the authors omit pain data? [PDF]
Rev Lat Am Enfermagem, 2020 Gray R, Brown E.
europepmc +1 more source
A Soft Robotic Model for Simulating Heart Valve Disease and Cardiac Interventions
Advanced Science, EarlyView.This paper introduces a fully synthetic fabrication methodology for a soft robotic, in‐vitro model of the left‐heart, complete with a functioning mitral valve apparatus. With a view towards patient‐specific modeling, we demonstrate physiological flow and pressure waveforms, tunable mitral valve function with clinical imaging compatibility, and its use ...
James Davies +14 more
wiley +1 more source
Advanced Science, EarlyView.The butterfly unfolded wing in an open form structure of botulinum neurotoxin type A (BoNT/A) at physiological‐state was confirmed at 2.85 Å resolution by cryo‐electron microscopy (cryo‐EM). Structure‐guided protein engineering significantly enhanced the receptor‐binding affinity, therapeutic efficacy, and safety of the engineered toxin variants ...
Wenrui Wang +16 more
wiley +1 more source
The impact of hydrotherapy on a patient’s perceived well-being: A critical review of the literature [PDF]
, 2016 Carere, Amy, Orr, Rob Marc
core +1 more source
Linearizing and Forecasting: A Reservoir Computing Route to Digital Twins of the Brain
Advanced Science, EarlyView.A new approach uses simple neural networks to create digital twins of brain activity, capturing how different patterns unfold over time. The method generates and recovers key dynamics even from noisy data. When applied to fMRI, it predicts brain signals and reveals distinctive activity patterns across regions and individuals, opening possibilities for ...
Gabriele Di Antonio +3 more
wiley +1 more source
Effect of meditation and relaxation therapy on preoperative anxiety and stress in oral squamous cell carcinoma patients scheduled for oral and maxillofacial surgery: An experimental study. [PDF]
Natl J Maxillofac SurgRaut SJ +4 more
europepmc +1 more source
Guided imagery relaxation therapy on preoperative anxiety: a randomized clinical trial. [PDF]
Rev Lat Am Enfermagem, 2018 Felix MMDS +5 more
europepmc +1 more source