Results 101 to 110 of about 180,313 (330)

Deciphering and Targeting the Schwannoma‐Neuron‐Macrophage Crosstalk for the Treatment of Schwannomatosis and Associated Pain

open access: yesAdvanced Science, EarlyView.
We established patient‐derived SWN cell lines and orthotopic PDX models that recapitulate patient pain phenotypes, alongside a novel intravital DRG imaging platform to track macrophage infiltration and neuronal pain responses. Using these models, we define HMGB1–CCL2–IL‐6 signaling crosstalk driving pain and identify EGF signaling as a key regulator of
Zhenzhen Yin   +17 more
wiley   +1 more source

An Open‐Source Pipeline for Calcium Imaging and All‐Optical Physiology in Human Stem Cell‐Derived Neurons

open access: yesAdvanced Science, EarlyView.
This work introduces an open‐source all‐optical platform for functional phenotyping of human stem cell‐derived neurons. The system integrates optogenetics, calcium imaging, automated acquisition, and analysis to resolve single‐cell and network activity, enabling longitudinal measurements, disease modeling, and pharmacological screening in preclinical ...
Wardiya Afshar‐Saber   +12 more
wiley   +1 more source

A Tac1‐Expressing Brainstem Pathway Underlies the Pathogenesis of Trigeminal Neuralgia

open access: yesAdvanced Science, EarlyView.
A critical TG‐Sp5CTac1‐PBNTac1 pathway drives trigeminal neuropathic pain (TNP). Tac1‐expressing parabrachial nucleus (PBNTac1) neurons exhibit heightened responses to innocuous stimuli in TNP, and chemogenetic inhibition of these neurons effectively prevents TNP development.
Liting Sun   +11 more
wiley   +1 more source

Superimposed Training-Based Channel Estimation for MIMO Relay Networks

open access: yesInternational Journal of Antennas and Propagation, 2012
We introduce the superimposed training strategy into the multiple-input multiple-output (MIMO) amplify-and-forward (AF) one-way relay network (OWRN) to perform the individual channel estimation at the destination.
Xiaoyan Xu   +4 more
doaj   +1 more source

A Soft Robotic Model for Simulating Heart Valve Disease and Cardiac Interventions

open access: yesAdvanced Science, EarlyView.
This paper introduces a fully synthetic fabrication methodology for a soft robotic, in‐vitro model of the left‐heart, complete with a functioning mitral valve apparatus. With a view towards patient‐specific modeling, we demonstrate physiological flow and pressure waveforms, tunable mitral valve function with clinical imaging compatibility, and its use ...
James Davies   +14 more
wiley   +1 more source

Relay Techniques for MIMO Wireless Networks with Multiple Source and Destination Pairs

open access: yesEURASIP Journal on Wireless Communications and Networking, 2006
A multiple-input multiple-output (MIMO) relay network comprises source, relay, and destination nodes, each of which is equipped with multiple antennas.
Shi Hui   +3 more
doaj  

Relaying for Multiuser Networks in the Absence of Codebook Information [PDF]

open access: yes, 2012
This work considers relay assisted transmission for multiuser networks when the relay has no access to the codebooks used by the transmitters. The relay is called oblivious for this reason.
Tian, Ye, Yener, Aylin
core  

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