Results 121 to 130 of about 6,433,381 (285)
Controlled release device Patent [PDF]
, 1968 Controlled release device for use in launching rockets or ...
Burcham, T. W.
core +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Accurate Identification of Protein Binding Sites for All Drug Modalities Using ALLSites
Advanced ScienceProteins interact with diverse molecular modalities, yet the incomplete identification of their binding sites has left the proteome‐wide druggability largely underexplored.
Minjie Mou +14 more
doaj +1 more source
Improving the performance of swift-water rescue quick release harnesses [PDF]
, 2014 This paper considered the effectiveness of empathic design modifications to quick release harness design. It was found that the critical element in effecting a rapid and efficient release was the tape length distal to the buckle/back-bar components.
Collins, L.,, Onions, C.
core
Identification of coronal heating events in 3D simulations
, 2017 The solar coronal heating problem is an open question since 1939. One proposed model for the transport and release of mechanical energy generated in the sub-phorospheric layers and photosphere is the nanoflare model that incorporates Ohmic heating which ...
Gudiksen, Boris V., Kanella, Charalambos
core +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
High-reliability release mechanism [PDF]
, 1971 Release mechanism employing simple clevis fitting in combination with two pin-pullers achieves high reliability degree through active mechanical redundancy. Mechanism releases solar arrays. It is simple and inexpensive and performs effectively. It adapts
Paradise, J. J.
core +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard +5 more
wiley +1 more source