Results 91 to 100 of about 1,181,754 (281)
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Архивъ внутренней медицины, 2014 In 24 patients with type 1 and 2 diabetes and 12 donors was shown that in diabetes the Nox releasing of membrane of blood formations is significantly enhanced.
Е. А. Агаджанова
doaj +1 more source
A New Method for Protecting Interrelated Time Series with Bayesian Prior Distributions and Synthetic Data [PDF]
, 2013 Organizations disseminate statistical summaries of administrative data via the Web for unrestricted public use. They balance the trade-off between confidentiality protection and inference quality.
Abowd, John M, Schneider, Matthew J
core +2 more sources
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
JDY455 Retrievable Multipurpose Releasing Packer
Shiyou jixie, 2015 To solve such problems with the anti-pollution packer as sealing failure and difficult releasing and fishing,the JDY455 retrievable multipurpose releasing packer has been developed.The packer is set by hydraulic two-stage setting tool,has a two-way slip ...
Wang Lingling +4 more
doaj
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Macroscopic Superpositions of Phase States with Bose-Einstein Condensates
, 2008 Quantum superpositions of macroscopically distinguishable states having distinct phases can be created with a Bose-Einstein condensate trapped in a periodic potential.
Pezze', L., Piazza, F., Smerzi, A.
core +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Current Opinion in Immunology, 1996 There is increasing evidence that human basophils accumulate at sites of chronic inflammation, and, in particular, in allergic asthma. Investigators have, therefore, become very interested in identifying proteins that activate these cells. Recently, the gene encoding a candidate for this function, a novel molecule, the IgE-dependent histamine-releasing
openaire +2 more sources