A detailed workflow for recombinant GALC production and characterization is presented to support enzyme replacement therapy for Krabbe disease. In vitro assays demonstrate that physiological GALC doses restore enzymatic activity and autophagic flux without affecting cell viability, whereas higher doses impair autophagy and reduce viability.
Ambra Del Grosso+5 more
wiley +1 more source
The test-retest reliability of the H-Reflex and swaymeter in women aged 30-65 years. [PDF]
Brownson-Smith R+6 more
europepmc +1 more source
Hydrogel‐Based Capacitive Sensor Model for Ammonium Monitoring in Aquaculture
Traditional techniques for monitoring aquaculture water quality, particularly ammonium levels, harm fish. This work presents a novel capacitive sensor with an ionic hydrogel transducer to monitor ammonium concentration in real time based on the ammonium‐induced hydrogel dissociation and osmotic pressure. Monitoring aquaculture water quality, especially
Mohammad Mirzaee+3 more
wiley +1 more source
Intra- and inter-rater reliability of ultrasound measurements of the levator ani muscle thickness in and M-mode in asymptomatic individuals: a cross-sectional study. [PDF]
Delgado-Pérez E+6 more
europepmc +1 more source
Bridging Nature and Technology: A Perspective on Role of Machine Learning in Bioinspired Ceramics
Machine learning (ML) is revolutionizing the development of bioinspired ceramics. This article investigates how ML can be used to design new ceramic materials with exceptional performance, inspired by the structures found in nature. The research highlights how ML can predict material properties, optimize designs, and create advanced models to unlock a ...
Hamidreza Yazdani Sarvestani+2 more
wiley +1 more source
Efficiency of ranked set sampling designs in power Lindley system reliability estimation with uncensored and right-censored data. [PDF]
Wu Z, Xiang L.
europepmc +1 more source
A Case‐Based Reasoning Approach to Model Manufacturing Constraints for Impact Extrusion
A hybrid modeling approach is presented that combines constraint‐based process modeling and case‐based reasoning. The model formalizes manufacturing constraints and integrates simulation data to model complex manufacturing processes. The approach supports manufacturability analysis during product design through an adaptive modeling environment.
Kevin Herrmann+5 more
wiley +1 more source
Anaesthesiologists' Non-Technical Skills in Denmark Form: cross-cultural adaptation, reliability and validity of Turkish version in paediatric surgery team. [PDF]
Celik N+7 more
europepmc +1 more source
A Different Perspective on the Solid Lubrication Performance of Black Phosphorous: Friend or Foe?
Researchers investigate black phosphorous (BP) as a standalone solid lubricant coating through ball‐on‐disc linear‐reciprocating sliding experiments in dry conditions. Testing on different metals shows BP doesn't universally reduce friction and wear. However, it achieves 33% friction reduction on rougher iron surfaces and 23% wear reduction on aluminum.
Matteo Vezzelli+5 more
wiley +1 more source