Results 91 to 100 of about 1,247,116 (346)

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Amputated life-testing based on extended Dagum percentiles for type of group inspection plans: optimal sample sizes, termination time ratios analysis

Scientific Reports
This paper introduces a novel approach to life-testing using Extended Dagum (EXD) percentiles within the framework of group inspection plans. The methodology focuses on optimizing sample sizes and analyzing termination time ratios to enhance the ...
Basma Ahmed, G. G. Hamedani, Getachew Tekle Mekiso, Yusra A. Tashkandy, M. E. Bakr, Eslam Hussam, Haitham M. Yousof   +6 more
doaj   +1 more source

Test-retest reliability of single-item assessments of immune fitness, mood, and quality of life

, 2023
Joris C. Verster, Kiki EW. Mulder, Marjolijn CE Verheul, Evi C. van Oostrom, Pauline A. Hendriksen, Andrew Scholey, Johan Garssen   +6 more
openalex   +1 more source

Management of SSME hardware life utilization [PDF]

Statistical and probabilistic reliability methodologies were developed for the determination of hardware life limits for the Space Shuttle Main Engine (SSME).
Pauschke, J. M.
core   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Design of Fatigue Life Test System of the Energy Efficient Heavy Transmission

Jixie chuandong, 2017
During the development process of heavy transmission,a cyclic loading fatigue life test is required to carry out in a certain load to verify the reliability of the internal gear,shaft,bearing,box,and the overall system.
Tan Wei, Xu Ran, Mi Lin, Chen Sheng
doaj  

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

The Japanese Translation of the Life Engagement Test: Reliability and Construct Validity in a College Student Population and a Working Adult Population [PDF]

, 2018
Katsunori Sumi
openalex   +1 more source

Development, Testing of Construct Validity and Reliability of Pakistan Senior Citizens Quality of Life- Measurement Tool (PSCQL-MT) [PDF]

, 2020
Hamid Mahmood, Ammara Waqar, Syed Amir Gilani, Muhammad Azeem Yaqoob, Ejaz Mahmood Ahmad Qureshi, Chhabi Lal Ranabhat, Asif Hanif, Awais Gohar   +7 more
openalex   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source