Results 71 to 80 of about 786,529 (300)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Validity and reliability of critical power field testing [PDF]

, 2014
PURPOSE To test the validity and reliability of field critical power (CP). METHOD Laboratory CP tests comprised three exhaustive trials at intensities of 80, 100 and 105 % maximal aerobic power and CP results were compared with those determined ...
Karsten, B, Hopker, J., Hopker, J, Stevens, L, Karsten, B., Stevens, L., Jobson, S., Beedie, C., Jobson, S A, Beedie, C, Jobson, S. A., Jobson, S.A.   +11 more
core   +1 more source

Validity and reliability of an adapted questionnaire measuring acceptance of traditional Chinese medicine among cancer patients

, 2023
Acceptance of traditional chinese medicine (TCM) treatment is important in cancer patients to improve treatment efficacy, reduce side effects and prolong prognosis and survival rate.
Sue, PH, Lim, YM, NG, FL, Tham, JS, Foo, CN, Zhu, X   +5 more
core   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Validity and Reliability of the Glaucoma Knowledge Level Questionnaire [PDF]

, 2018
Objectives: The present study was conducted to develop an instrument for measuring adults’ glaucoma knowledge levels and to establish the instrument’s validity and reliability.
Muhammed Fatih Önsüz, Zeynep Demirtaş, Aziz Soysal, Nilgün Yıldırım, Selma Metintaş, Gökçe Dağtekin   +5 more
core   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Validity, reliability, and responsiveness of a new short Visual Simplified Respiratory Questionnaire (VSRQ©) for health-related quality of life assessment in chronic obstructive pulmonary disease

International Journal of COPD, 2008
T Perez1, B Arnould2, J-M Grosbois3, V Bosch2, I Guillemin2, M-L Bravo4, M Brun4, A-B Tonnel1 on behalf of TIPHON Study Group1Centre Hospitalier Régional Universitaire (CHRU), Lille, France; 2Mapi Values, Lyon, France; 3Service de Pneumologie,
T Perez, B Arnould, J-M Grosbois, V Bosch, I Guillemin, et al   +5 more
doaj  

Reliability and Validity of the Tinnitus Handicap Inventory: A Clinical Study of Questionnaires

, 2022
BACKGROUND: The aim of this study is to observe the application of the Chinese version of Tinnitus Handicap Inventory-China in Tinnitus patients and verify its reliability and validity.
Guangyu Lui, Ming Li, Lui, Guangyu, Li, Ming, Huo, Yan, Ping, Huang, Yan Huo, Zhang, Jianning, Richard S. Tyler, Tyler, Richard S., Jianning Zhang, Huang Ping   +11 more
core   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Reliability and validity of the Persian version of psoriatic arthritis screening questionnaire

Caspian Journal of Internal Medicine, 2023
Background: The Early Arthritis for Psoriatic Patients (EARP) questionnaire is a fast and simple way to screen psoriatic arthritis. This study was carried out to investigate the diagnostic accuracy of the Persian version of the Early Arthritis for ...
Azar Shirzadian Kebria, Abolfazl Eftekhari, Khadijeh Ezoji, Soudabeh Tirgar tabari, Zeinab Aryanian, Soraya Khafri, Mansour Babaei   +6 more
doaj