Results 61 to 70 of about 1,882,832 (297)

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Validation of questionnaires for the measurement of health variables: Fundamental concepts

Medwave
In clinical practice and population health, it is common to use questionnaires to assess conditions or variables that are not directly observable. However, the construction and validation of these instruments or questionnaires are often poorly understood.
Natalia Riva, Diego Grandi, Benjamín Cruzat, Ruben Alvarado   +3 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Assessing the environmental characteristics of cycling routes to school : a study on the reliability and validity of a Google Street View-based audit [PDF]

, 2014
Background: Google Street View provides a valuable and efficient alternative to observe the physical environment compared to on-site fieldwork. However, studies on the use, reliability and validity of Google Street View in a cycling-to-school context are
Cardon, Greet, De Bourdeaudhuij, Ilse, Ducheyne, Fabian, Van Dyck, Delfien, Vanwolleghem, Griet   +4 more
core   +3 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Reliability and concurrent validity between two-dimensional and three-dimensional evaluations of knee valgus during drop jumps

Open Access Journal of Sports Medicine, 2016
Alexis Ortiz1,  Martin Rosario-Canales2,3,  Alejandro Rodríguez3, Alexie Seda3, Carla Figueroa3, Heidi L Venegas-Ríos4 1School of Physical Therapy, Texas Woman’s University, Houston, TX, 2Department of Anatomy & ...
Ortiz A, Rosario-Canales M, Rodríguez A, Seda A, Figueroa C, Venegas-Ríos HL   +5 more
doaj  

Validity, reliability, acceptability, and utility of the Social Inclusion Questionnaire User Experience (SInQUE): a clinical tool to facilitate social inclusion amongst people with severe mental health problems. [PDF]

, 2020
BACKGROUND: Individuals with severe mental health problems are at risk of social exclusion, which may complicate their recovery. Mental health and social care staff have, until now, had no valid or reliable way of assessing their clients' social ...
Bousfield, J, Harrison, I, Killaspy, H, Lloyd-Evans, B, Mezey, G, Payne, S, White, S   +6 more
core   +2 more sources

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

The Reliability and Validity of FMS ver.a.j [PDF]

, 2012
福盛・森川（2003）によってフォーカシング的態度を測定する体験過程尊重尺度（the Focusing Manner Scale；FMS）が開発されて以来、FMS を用いた研究が日本国内では盛んになされてきた。それらの研究結果は、Aoki, Kawasaki & Miyake（2009）によって英語で概観が発表されるまでは日本語でのみ発表されており、海外の研究者に知られることはなかった。筆者は日本国内外の研究者らと共に、英語版を試作したが、その過程で改定が成され、原版のFMS ...
Aoki Tsuyoshi, 青木 剛
core   +1 more source

Reliability and validity of two widely-used worry questionnaires: self-report and self-peer convergence [PDF]

, 1998
The reliability and validity of the Penn State Worry Questionnaire (PSWQ) and the Worry Domains Questionnaire (WDQ) were examined with self-ratings from a non-clinical sample of 148 students in a test-retest design across four weeks.
Borkenau, Borkovec, Cronbach, Crowne, Davey, Davey, Joachim Stöber, Joormann, Lück, McCann, McCrae, McCrae, Meyer, Molina, O'Neill, O'Neill, Shrout, Stöber, Tallis, Tallis, Watson, Wells   +21 more
core   +1 more source