Results 71 to 80 of about 780,876 (300)

Validation of questionnaires for the measurement of health variables: Fundamental concepts

Medwave
In clinical practice and population health, it is common to use questionnaires to assess conditions or variables that are not directly observable. However, the construction and validation of these instruments or questionnaires are often poorly understood.
Natalia Riva, Diego Grandi, Benjamín Cruzat, Ruben Alvarado   +3 more
doaj   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

The reliability and validity of the Lane Agility Test for collegiate basketball players [PDF]

, 2012
Agility is the ability to change body direction, or position in space. The game of basketball requires intermittent starts, stops, changes of direction, etc. Several tests have been developed to measure agility. The purpose of this study was to determine
Brown, Ashley E.
core  

The Patient-Rated Wrist and Hand Evaluation: a systematic review of its validity and reliability [PDF]

, 2014
The Patient-Rated Wrist and Hand Evaluation is a region specific, patient reported outcome measure that aims to evaluate pain and disability of the wrist and hand.
Taylor, J., Kersten, P.
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Reliability and concurrent validity between two-dimensional and three-dimensional evaluations of knee valgus during drop jumps

Open Access Journal of Sports Medicine, 2016
Alexis Ortiz1,  Martin Rosario-Canales2,3,  Alejandro Rodríguez3, Alexie Seda3, Carla Figueroa3, Heidi L Venegas-Ríos4 1School of Physical Therapy, Texas Woman’s University, Houston, TX, 2Department of Anatomy & ...
Ortiz A, Rosario-Canales M, Rodríguez A, Seda A, Figueroa C, Venegas-Ríos HL   +5 more
doaj  

Construct validity and reliability of the Brazilian version of the Falls Efficacy Scale in patients with COPD

Pulmonology, 2020
Introduction and objective The Brazilian version of Falls Efficacy Scale (FES-BR) used to assess the fear of falling, has not yet been validated in patients with Chronic Obstructive Pulmonary Disease (COPD).
C.F. Scremim, B.F.P.M.C. Simões, J.A. de Barros, S. Valderramas   +3 more
doaj   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source