Results 51 to 60 of about 18,162,333 (306)
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Reliability Evaluation Metrics for Open Source Software Selection
Journal of Measurement Science and Instrumentation, 2010 Recently,Open Source Software（OSS）is so widely used not only by companies for development but also by common users instead of commercial software.However,the number of OSS is vast,and its quality varies from low to high.So how people can evaluate OSS and
Jing-shu JIN, Hoo-jae LEE, Sung-yul RHEW
doaj
Evaluating Evidence Reliability on the Basis of Intuitionistic Fuzzy Sets
Information, 2018 The evaluation of evidence reliability is still an open topic, when prior knowledge is unavailable. In this paper, we propose a new method for evaluating evidence reliability, in the framework of intuitionistic fuzzy sets. The reliability of evidence was
Wenhua Wu, Yafei Song, Weiwei Zhao
doaj +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Rigakuryoho Kagaku, 1997 客観的な評価とは，信頼性の高い評価のことを指す。たとえ測定方法が，測る目的に適した妥当なものであったとしても，測定のばらつきが大きいと，発見したい「ちがい」が，測定誤差の中に埋もれてしまう可能性が高くなる。本稿では，級内相関（ICC：Intraclass Correlation Coefficient）を用いた検者内信頼性，検者間信頼性の求めかたを概説する。
openaire +2 more sources
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source