Exploring tradeoffs in pleiotropy and redundancy using evolutionary computing
, 2004 Evolutionary computation algorithms are increasingly being used to solve optimization problems as they have many advantages over traditional optimization algorithms.
Abbott, Derek +5 more
core +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
Cross-Layer Reliability, Energy Efficiency, and Performance Optimization of Near-Threshold Data Paths [PDF]
, 2020 Mehdi B. Tahoori +1 more
openalex +1 more source
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Optimizing Costs in a Reliability System under Markovian Arrival of Failures and Reposition by K-Policy Inspection [PDF]
, 2022 Delia Montoro‐Cazorla +1 more
openalex +1 more source
Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system
FEBS Open Bio, EarlyView.An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková +3 more
wiley +1 more source
Fragility analysis of concrete elevated water tanks under seismic loads
Fracture and Structural Integrity, 2021 The design of concrete elevated water tanks involves several kinds of uncertainties. Traditionally, the design of these structures is based on a deterministic analysis.
Hocine Hammoum +5 more
doaj
High Power Solid State Retrofit Lamp Thermal Characterization and Modeling [PDF]
, 2012 Thermal and thermo-mechanical modeling and characterization of solid state lightening (SSL) retrofit LED lamp are presented in this paper. Paramount importance is to design SSL lamps for reliability, in which thermal and thermo-mechanical aspects are key
Formanek, J. +4 more
core +1 more source