Cilostazol in patients with heart failure and preserved ejection fraction—The CLIP‐HFpEF trial
ESC Heart Failure, Volume 12, Issue 2, Page 1437-1446, April 2025.• Cilostazol is an oral PDE‐3 inhibitor that may have advantageous effects in heart failure with preserved ejection fraction (HFpEF). • Cilostazol significantly improved short‐term heart failure‐related health status scores (KCCQ‐12) and NT‐proBNP levels when compared to placebo.
Norman Aiad +9 more
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Identify the significant landscape characteristics for the perceived restorativeness of 8 perceived sensory dimensions in urban green space. [PDF]
HeliyonWang S, Li A.
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European Journal of Organic Chemistry, EarlyView.Diarylethene‐containing cyclic tubulysin analogues were designed, synthesized, and evaluated as light‐responsive cytotoxic agents. One analogue showed reversible photoswitching, photoregulated tubulin polymerization inhibition, and photoform‐dependent cytotoxicity.
Anna Iampolska +9 more
wiley +1 more source
Exploration, EarlyView.Rheumatoid arthritis (RA) is the most prevalent inflammatory arthropathy globally and remains incurable nowadays. Herein, an M2 macrophage‐mimetic hybrid nanoplatform (Cel@M2‐L‐MSN) is constructed for concerted RA therapy through joint‐specific accumulation, on‐demand drug release, inflammation resolution, ROS clearance, along with macrophage ...
Yi Xiao +11 more
wiley +1 more source
Navigating Adversity: Psychosocial Transformation, Service Advocacy, and End-of-Life Perceptions Among Family Caregivers of PLWHA During Inpatient Treatment in Hunan, China. [PDF]
Patient Prefer AdherenceShi C +6 more
europepmc +1 more source
An Ocular Surface‐Targeting Nucleic Acid Hydrogel for Efficient Dry Eye Disease Treatment
Exploration, EarlyView.A self‐assembled nucleic acid hydrogel modified with mucin‐1 (MUC1) aptamer is developed, which can actively target the mucin layer on the ocular surface and significantly extend its retention time after distillation. Inside the hydrogel, therapeutic siRNA is embedded and can effectively silence the inflammation gene expression, subsequently restoring ...
Yuhe Liu +12 more
wiley +1 more source
Archeo-Inspiration from the Cultural History of Glass: Historic Accounts, Anecdotes and Hard Facts as Challenges to Modern Material Science. [PDF]
Adv Matervon Contzen E +3 more
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Enhancing Optogenetics‐Based Cancer Therapy Via Nanotechnology
Exploration, EarlyView.Nanotechnology enhances optogenetics‐based cancer therapy through improved delivery systems and non‐invasive optical regulation. It further enables precise and programmable control of optogenetic living therapeutics for localized antitumor responses.
Honggang Shen +8 more
wiley +1 more source
Ethnobotany around the Virovitica Area in NW Slavonia (Continental Croatia)-Record of Rare Edible Use of Fungus Sarccoscypha coccinea. [PDF]
Plants (Basel)Vitasović-Kosić I +4 more
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