Results 31 to 40 of about 3,945,936 (296)

The British Relief Association and the Great Famine in Ireland

open access: yesRevue Française de Civilisation Britannique, 2014
The historiography of the Great Famine in Ireland has largely been concerned with the role played by the British Government in providing relief in the years after 1845. Less attention has been given to the involvement of private charity.
Christine Kinealy
doaj   +1 more source

Maternal near miss hospitalizations in the Borana Zone, Ethiopia: A facility-based longitudinal cross-sectional study

open access: yesJournal of Public Health Research
Background: Maternal near miss refers to a woman who nearly died but survived a complication that occurred during pregnancy, childbirth, or within 42 days of pregnancy termination. While there has been considerable progress in reducing maternal mortality
Boboh Kamangira   +4 more
doaj   +1 more source

Inter-Organizational Partnering Strategies in Disaster Response: A Complex Network Perspective

open access: yesSystems, 2023
Establishing appropriate inter-organizational partnership in disaster response is of great help to the improvement of disaster relief performance.
Chenyu Liu, Qian Shi
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

Coordination of relief items procurement in humanitarian logistic based on quantity flexibility contract

open access: yesInternational Journal of Disaster Risk Reduction, 2018
Nowadays, coordination of relief items procurement in humanitarian logistics has become one of the main challenges of disaster management. In this paper, we utilize a quantity flexibility contract (QFC) to coordinate ordering activities in a three ...
F. Nikkhoo, A. Bozorgi-Amiri, J. Heydari
semanticscholar   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Imam Khomeini Relief Foundation, an Organization by the People for the People [PDF]

open access: yesIranian Journal of Public Health, 2009
Imam Khomeini Relief Foundation (IKRF) was officially established on March 5th 1979, to aid the underprivileged, allevi­ate poverty and improve the self sufficiency of the needy people.
MH Nicknam
doaj   +1 more source

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