Results 51 to 60 of about 545,136 (279)
Cannabinoid CB1 Receptor in Nociceptors Mediates Postoperative Analgesia via ASIC3 Inhibition
Advanced Science, EarlyView.CB1R and ASIC3 are co‐expressed in CGRP+ nociceptors of mouse DRG. Plantar incision triggers an upregulation of ASIC3 and activation of ASIC3+ neurons, driving mechanical allodynia. CB1R activation suppresses ASIC3 function and downstream ERK1/2 phosphorylation, thereby braking nociceptive signaling and accelerating pain resolution.
Kangtai Xu +13 more
wiley +1 more source
Digitally-Assisted Stone Carving of a Relief Sculpture for the Parliament Buildings National Historic Site of Canada [PDF]
ISPRS Annals of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2015 The emerging field of digital fabrication is a process where three-dimensional datasets can be directly transferred to fabrication equipment to create models or even 1:1 building elements.
J. Hayes +4 more
doaj +1 more source
Advanced Science, EarlyView.Early‐life manganese exposure induces behavioral deficits and aberrant hippocampal synaptic remodeling by enhancing microglial phagocytosis in young adult male mice. Mechanistically, manganese promotes Yin Yang 1 (YY1)/triggering receptor expressed on myeloid cells 2 (TREM2) signaling through enhanced HIF1α‐mediated transcription and suppressed SMURF2 ...
Keyu Chen +4 more
wiley +1 more source
Perseus as Alter Ego of Ferdinand I [PDF]
Studia Hercynia, 2016 The paper analyses three relief sculptures that decorate spandrels of the northern façade of the Prague Bel‑ vedere, which was built by Ferdinand I between 1538 and ca. 1550. Their uniqueness consists in that it is the first series inspired by the myth
Jan Bažant
doaj
Advanced Science, EarlyView.Lactate accumulation after SCI promotes H4K12la lactylation, which upregulates NDUFS7, triggering mitochondrial RET and ROS, enforcing pro‐inflammatory microglial polarization. MM@mPTC, a biomimetic nanotherapeutic, degrades LDHA in activated microglia, reducing H4K12la lactylation and blocking RET, thus curbing ROS, fostering a reparative phenotype ...
Chenglong Hong +13 more
wiley +1 more source
Advanced Science, EarlyView.This 28 g robot incorporates innovative ring structures and anisotropic origami springs to achieve high speeds and exceptional load capacity. It successfully carries a 100 g payload while ascending walls or ceilings at speeds of up to 8 and 20 cm/s, demonstrating enhanced adhesion and maneuverability over current climbing robots.
Xinxian Chen +5 more
wiley +1 more source
A.D. German Warehouse, Richland Center, Wisconsin
, 2011 Exterior, relief sculpture trim, detailLater renovated as the Richland ...
Wright, Frank Lloyd, 1867-1959
core +5 more sources
Advanced Science, EarlyView.In this study, we demonstrate that aberrant MEKK3 signaling in endothelial cells and microglia drives the progression of cerebral cavernous malformations (CCMs). Furthermore, we identify DPDH as a potent small‐molecule MEKK3 inhibitor with substantial therapeutic potential for CCM treatment.
Weiwei Zheng +17 more
wiley +1 more source
Zaragoza : Sculpture en bas-relief
, 1986 Musée de Zaragoza, Municipio de La Piedad, Michoacán. Sculpture en bas-relief à tesson provenant du "Cerro de las Chichimecas"
Michoacán I, Projet +1 more
core +2 more sources