Results 61 to 70 of about 265,741 (266)
Advanced Science, EarlyView.CHCHD10 loss in Alzheimer's disease is associated with mitochondrial dysfunction, epigenomic disruption, and tau pathology. Restoration of CHCHD10 shifts DNA methylation toward a non‐disease state and reduces tau and amyloid pathology, with KATNAL2 acting as a downstream effector.
Teresa M. Thomas +13 more
wiley +1 more source
COVID-19 Pandemic and Spiritual Challenges in Iran
Health, Spirituality and Medical Ethics, 2021 ndividuals encounter unprecedented critical conditions globally. The Coro navirus Disease 2019 (COVID-19) has spread worldwide [1]. In addition to biopsychological health, this crisis has affected other areas of human life, like the ...
Fatemeh Shirzad, Ruhollah Sedigh
doaj
Advanced Science, EarlyView.ABSTRACT Glioblastoma multiforme (GBM) remains largely incurable due to the blood‐brain barrier (BBB) and immunosuppressive microenvironment. While boron neutron capture therapy (BNCT) selectively eradicates tumor cells via 10B(n, α)‐7Li reactions, its clinical potential in GBM is unrealized because of the suboptimal pharmacokinetics of conventional ...
Jiawen Chen +22 more
wiley +1 more source
Religious Instruction and Religiousness in Germany [PDF]
Religious Education, 1906 For a brief general account of the German Religious Instruction, see paper by the writer in the Proceedings of the R. E. A. (or 1905, pp. 261‐208.
openaire +1 more source
Non‐Noble Metal Nanocatalysts for Hydrogen Evolution
Advanced Science, EarlyView.Recent overviews and latest developments of diverse classes of non‐noble catalysts for application toward high‐performance photocatalysis, thermocatalytic steam reforming, and electrocatalysis. Toward sustainability objectives, several advanced characterization tools in combination with the latest breakthroughs in machine learning for material ...
Lina Jaya Diguna +7 more
wiley +1 more source
Mechanical Flexibility Enables DNA Origami to Overcome Steric Confinement in Mucus
Advanced Science, EarlyView.Mechanical flexibility is introduced as a design parameter to enhance nanocarrier transport in mucus. Using DNA origami, flexibility is decoupled from size, shap and surface chemistry, revealing improved passage through confined hydrogel networks. While surface passivation reduces aggregation, flexibility further boosts transport, offering a general ...
Matteo Tollemeto +5 more
wiley +1 more source
Advanced Science, EarlyView.Cross‐disciplinary endeavors are blossoming across the broad chemical sciences. This perspective provides a glimpse into the rewarding interdisciplinary journey taken by the Charles Loh research group in pioneering the σ‐hole based catalytic glycosylation strategy.
Charles C. J. Loh
wiley +1 more source
Gap‐Free Information Transfer in 4D‐STEM via Fusion of Complementary Scattering Channels
Advanced Science, EarlyView.Fused Full‐Field STEM (FF‐STEM) is introduced as a 4D‐STEM imaging modality that combines direct ptychography with tilt‐corrected dark‐field reconstruction in a single acquisition. Fourier‐space fusion using Wiener‐type spectral weighting closes the low‐frequency contrast gap inherent to bright‐field methods, delivering gap‐free, dose‐efficient, near ...
Shengbo You +15 more
wiley +1 more source
A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy
Advanced Science, EarlyView.Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu +17 more
wiley +1 more source