Results 41 to 50 of about 59,622 (239)

Modelos ortogonais para a estimativa multivariada de VAR (Value-at-risk) para risco de mercado: um estudo de caso comparativo

Revista de Economia Mackenzie, 2011
O presente trabalho tem como objetivo explorar diferentes modelos de estimativa da distribuição conjunta de fatores para risco de mercado, com ênfase nos modelos ortogonais. Foram explorados cinco modelos: 1.
João Luiz Chela, Jean Carlos Abrahão, Luiz Fernando Ohara Kamogawa   +2 more
doaj  

Remimazolam Ameliorates Autistic‐Like Behaviors via Suppression of Ferroptosis in VTA Dopaminergic Neurons in a Mouse Model of ASD

Advanced Science, EarlyView.
The ultra‐short‐acting sedative remimazolam has a sustained therapeutic effect on the core symptoms of VPA‐exposed mice. Remimazolam, a GABA agonist, exerts its therapeutic effects by protecting dopamine neurons in the VTA of VPA‐exposed mice. Meanwhile, ferroptosis is the critical mechanism by which remimazolam protects VTA dopaminergic neurons and ...
Yuxin Zhang, Jianwei Lin, Chaoyang Tong, Xin Fu, Mengqin Shan, Yue Huang, Kan Zhang, Jijian Zheng   +7 more
wiley   +1 more source

The effects of Valerian on sleep spindles in a model of neuropathic pain [PDF]

Sleep Science
Introduction: Valeriana officinalis is known to be one of the most famous herbal supplements for the treatment of anxiety and insomnia. Despite its widespread use in most countries all around the world, there is little scientific information and research
Ashkan Soltani, Farideh Bahrami, Zahra Bahari, Zeinab Shankayi, Mehdi Graily-Afra, Hedayat Sahraei   +5 more
doaj   +1 more source

Loss of VMP1 Impairs Tight Junction Recycling and Aggravates Intestinal Barrier Dysfunction in Inflammatory Bowel Disease

Advanced Science, EarlyView.
This study identifies vacuole membrane protein 1 (VMP1) as a critical regulator of intestinal epithelial barrier homeostasis. VMP1 facilitates the recruitment of CORO1C to late endosomes, supporting Retromer‐mediated recycling of the tight junction protein Occludin.
Jiawei Zhao, Jianjun Zou, Chen Zhou, Yingui Wang, Yiman Liu, Yanqing Zhou, Yuxiang Wang, Xinyu Zhang, Huishu Yang, Hongjie Yin, Dongsheng Bai, Yue Zhao, Na Lu   +12 more
wiley   +1 more source

Controlled Synthesis of a New Class of Heterostructured Metal Oxides (Cerium, Thorium, Uranium)/Calcium Fluoride Core‐Shell Nanocrystals With Atomically Coherent Interfaces

Angewandte Chemie, EarlyView.
Precisely engineered heterostructured metal oxide‐based MO2 / CaF2 (M = Ce, Th, U) core‐shell nanocrystals are synthesized with atomic‐level control over size, shell thickness, and interface coherence, expanding heterostructure design principles to cerium oxide and actinide oxide systems for the first time.
Dejing Meng, Radian Popescu, Carmen M. Andrei, Jérôme Himbert, Eduard Madirov, Jacob A. Branson, Emily M. Reynolds, Tim Prüßmann, Jörg Göttlicher, Tonya Vitova, Niko Hildebrandt, Yolita Eggeler, Bryce S. Richards, Olaf Walter, Damien Hudry   +14 more
wiley   +2 more sources

Dorsal Raphe VIP Neurons Are Critical for Survival‐Oriented Vigilance

Advanced Science, EarlyView.
DRNVIP neurons in mice and primates are strategically positioned to influence the central extended amygdala via feedback loops. They regulate the excitability of PKC‐δ neurons in the ovBNST and CeA through glutamate release. Their ablation heightens activity in these regions, disrupts active‐phase sleep architecture, enhances risk assessment behaviors ...
Adriane Guillaumin, Emma Perrot, Thibault Dhellemmes, Laura Boi, Daniel De Castro Medeiros, Christelle Glangetas, Sylvie Dumas, Sandra Dovero, Nathalie Biendon, Elodie Ladeveze, Maëlle Hardel, Marc Landry, Erwan Bezard, Jérôme Baufreton, Gilberto Fisone, François Georges   +15 more
wiley   +1 more source

The Evolution of Symptoms in Prodromal Dementia With Lewy Bodies: A Naturalistic History Study in a Chinese Memory Clinic

AGING MEDICINE, EarlyView.
The study characterized the evolution of symptoms prior to a diagnosis of DLB in people attending a Chinese memory clinic. Anxiety was the earliest recognized individual psychiatric symptom of DLB, followed by depression and memory decline. ABSTRACT Objectives Given that DLB is the second most common neurodegenerative dementia and early detection is ...
Ming Zhang, Tao Li, Dag Aarsland, Xiaozhen Lv, Jing Wang, Teng Xie, Xin Yu, Huali Wang   +7 more
wiley   +1 more source

Can outsourcing pest and disease control help reduce pesticide expenditure? Evidence from rice farmers

Agribusiness, EarlyView.
Abstract Outsourcing pest and disease control (PDC) has grown rapidly worldwide, especially in developing countries. Although numerous studies have investigated various advantages of outsourcing PDC, little is known about its impact on pesticide expenditure.
Pengcheng Wang, Wanglin Ma, Mengling Diao   +2 more
wiley   +1 more source

Assessment of the state of the cenopopulation of Cousinia mindschelkensis B. Fedtsch. of Karakuys Gorge in the Karatau Reserve [PDF]

BIO Web of Conferences
The article presents an assessment of the state of the cenopopulation of Cousinia mindschelkensis B. Fedtsch. of Karakuys gorge in Karatau reserve. The data on distribution and cenoflora of the rare endemic species Cousinia mindschelkensis were obtained.
Kenesbay Akerke, Kurmantayeva Alfia, Sitpayeva Gulnara   +2 more
doaj   +1 more source

A Hypothalamic Switch for REM and Non-REM Sleep [PDF]

Neuron, 2018
Rapid eye movement (REM) and non-REM (NREM) sleep are controlled by specific neuronal circuits. Here we show that galanin-expressing GABAergic neurons in the dorsomedial hypothalamus (DMH) comprise separate subpopulations with opposing effects on REM versus NREM sleep.
Chen, Kai-Siang, Xu, Min, Zhang, Zhe, Chang, Wei-Cheng, Gaj, Thomas, Schaffer, David V, Dan, Yang   +6 more
openaire   +4 more sources