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The effects of pramipexole in REM sleep behavior disorder [PDF]

open access: possibleNeurology, 2003
The authors evaluated the effects of pramipexole, a dopaminergic D2-D3 receptor agonist, on eight patients with idiopathic REM sleep behavior disorder. Five patients reported a sustained reduction in the frequency or intensity of sleep motor behaviors, which was confirmed by video recording, although no change was observed for the percentage of phasic ...
Jacques Montplaisir   +3 more
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REM Sleep Behavior Disorder

2014
Rapid eye movement (REM) sleep behavior disorder (RBD) was formally identified and named in 1986–1987 and is characterized by loss of REM sleep atonia with the release of complex, aggressive, and violent behaviors that are often simultaneous enactments of abnormal dreams involving confrontation by unfamiliar people and animals, with the dreamer rarely ...
Michael J. Howell, Carlos H. Schenck
openaire   +2 more sources

Breakdown in REM sleep circuitry underlies REM sleep behavior disorder

Trends in Neurosciences, 2014
During rapid eye movement (REM) sleep, skeletal muscles are almost paralyzed. However, in REM sleep behavior disorder (RBD), which is a rare neurological condition, muscle atonia is lost, leaving afflicted individuals free to enact their dreams. Although this may sound innocuous, it is not, given that patients with RBD often injure themselves or their ...
John H. Peever   +2 more
openaire   +3 more sources

REM Sleep Behavior Disorder and Other REM Parasomnias

CONTINUUM: Lifelong Learning in Neurology, 2023
ABSTRACT OBJECTIVE This article reviews rapid eye movement (REM) sleep behavior disorder (RBD) and other REM sleep parasomnias, particularly recurrent isolated sleep paralysis and nightmare disorder. LATEST DEVELOPMENTS People with RBD have dream enactment behaviors that ...
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Impulse Control Disorders in REM Sleep Behavior Disorder

Current Treatment Options in Neurology, 2019
This paper reviews clinical and pathophysiological features of both impulse control disorders (ICDs) and REM sleep behavior disorder (RBD) in Parkinson's disease (PD), as well as current evidences of their association. Then, we suggest recommendations to manage PD patients with RBD in order to prevent this potentially devastating psychiatric ...
Fantini, Maria Livia   +2 more
openaire   +4 more sources

REM Sleep Behavior Disorder and Narcolepsy

CNS & Neurological Disorders - Drug Targets, 2009
REM (rapid eye movement) sleep behavior disorder (RBD) is a well known parasomnia [1]. Its first description in humans dates back to 1985, and its first description in narcoleptic patients to 1992. Although the precise pathophysiology of RBD remains unclear, it is likely, in the case of RBD associated with narcolepsy, that the altered function of ...
openaire   +3 more sources

REM Sleep Behavior Disorder

Sleep Medicine Clinics, 2011
Rapid eye movement (REM) sleep behavior disorder (RBD) is a REMsleep-related parasomnia, characterized by dream-enacted behaviors ranging from simple vocalizations or mumbling sleep talk to full-blown violent behaviors leading to injuries of the patient and/or the bed partner.
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The influence of sleep disordered breathing in REM sleep behavior disorder

Sleep Medicine, 2017
Because both REM sleep behavior disorder (RBD) and Obstructive Sleep Apnea (OSA) can present with similar symptoms, it is important to understand the influence of OSA in the clinical manifestations of RBD and whether RBD modulates OSA severity. Our objectives were to compare: 1.
Paulo Bugalho   +3 more
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REM Sleep Behavior Disorder in Psychiatric Populations

The Journal of Clinical Psychiatry, 2010
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Lam, SP   +7 more
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Ethical Considerations in REM Sleep Behavior Disorder

CONTINUUM: Lifelong Learning in Neurology, 2013
A patient diagnosed with REM behavior sleep disorder (RBD) has as much as a 65% risk of developing an α-synucleinopathy. Currently, it is not possible to predict whether an individual will develop a disease, or, if so, which disease.The neurologist treating the patient must consider (1) the difference between disclosing a diagnosis and disclosing the ...
Glen P. Greenough, Stephanie Vertrees
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