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REM Sleep Behavior Disorder in Narcolepsy
2018Narcolepsy is a central nervous system hypersomnia characterized by a loss of boundaries between wake and sleep and altered manifestations of rapid eye movement (REM) sleep. Type 1 narcolepsy (NT1), formerly called narcolepsy with cataplexy, is the primary form of narcolepsy due to the loss of hypothalamic hypocretin (orexin)-producing neurons and ...
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Pathophysiologic mechanisms in REM sleep behavior disorder
Current Neurology and Neuroscience Reports, 2007REM sleep behavior disorder (RBD) is a fascinating experiment in nature predicted by animal studies in 1964. A defining feature of REM sleep is active paralysis of all somatic musculature (sparing the diaphragm to permit respiration). RBD is characterized by the absence of REM atonia, permitting the appearance of dream-enacting behaviors. These oneiric
Michel A. Cramer Bornemann +2 more
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Update on the pharmacology of REM sleep behavior disorder
Neurology, 2006REM sleep behavior disorder (RBD) is characterized by complex behavioral manifestations in response to dream content that may cause sleep disruption or injuries to the patient or the bed partner. In this case, the patients need treatment to control their symptoms.
Jacques Montplaisir +2 more
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Genetics of REM Sleep Behavior Disorder
2018Studies on the genetic basis of REM sleep behavior disorder (RBD) have emerged only recently, so we are just beginning to understand how genetics affect the risk for RBD and its progression to the different synucleinopathies—Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy. Of the two genes most commonly associated
Ziv Gan-Or +3 more
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REM Sleep Behavior Disorder in Narcolepsy with Cataplexy
2008Narcolepsy with cataplexy (NC) is a chronic disease characterized by excessive daytime sleepiness, striking transitions from wakefulness into rapid eye movement (REM) sleep, typically associated with cataplexy and other phenomena due to the abnormal occurrence of REM sleep elements during wakefulness (sleep paralysis and hallucinations) and frequent ...
Plazzi G., Dauvilliers Y.
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2001
History REM sleep behavior disorder (RBD) was first formally identified in 1986 by Schenck and Mahowald in five elderly subjects presenting similar motor behavioral patterns during REM sleep consisting of violent dream-enacting behaviors. Although there already existed anecdotal reports of similar episodes arising from REM sleep during tricyclic anti ...
Manni R., Terzaghi M.
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History REM sleep behavior disorder (RBD) was first formally identified in 1986 by Schenck and Mahowald in five elderly subjects presenting similar motor behavioral patterns during REM sleep consisting of violent dream-enacting behaviors. Although there already existed anecdotal reports of similar episodes arising from REM sleep during tricyclic anti ...
Manni R., Terzaghi M.
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Diagnosis of REM Sleep Behavior Disorder
2018This chapter gives an overview of the development of current diagnostic criteria for REM sleep behaviour disorder (RBD) and specifies qualitative and quantitative diagnostic polysomnographic (PSG) criteria. Minor differences and controversies between the International Classification of Sleep Disorders (ICSD), Third Edition (ICSD-3), and the Diagnostic ...
Ambra Stefani +2 more
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Acute REM Sleep Behavior Disorder
2018REM sleep behavior disorder (RBD) may occur acutely or subacutely, irrespective of age and sex. RBD or isolated REM sleep without atonia (RSWA) has been associated with various medications, or substance use/abuse, or abrupt withdrawal states. Less frequently, structural brain lesions (vascular, demyelinating disease, tumors), especially in the pontine ...
Naoko Tachibana, Federica Provini
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Neuropathology of REM Sleep Behavior Disorder
2018The neuropathology of RBD demonstrates the very strong association of alpha-synucleinopathy neurodegeneration with RBD, with complexities involving clinical synucleinopathy subtypes; prodromal stages; heterogeneous phenoconversion timelines from idiopathic RBD (iRBD) to overt neurodegeneration; distribution of synuclein pathology in the central ...
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