Results 141 to 150 of about 59,932 (250)
Pharmacoepidemiology and Drug Safety, Volume 35, Issue 1, January 2026.ABSTRACT Purpose To describe the characteristics of adults who had a severe coronavirus disease 2019 (COVID‐19) outcome during a timeframe that nirmatrelvir/ritonavir (NMV‐r; Paxlovid) was available, to assess medical eligibility and receipt of NMV‐r before presentation to acute care.
Sylvia Aponte‐Hao +10 more
wiley +1 more source
Physiologically‐Based Pharmacokinetic Modeling of the PARP Inhibitor Niraparib
CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 1, January 2026.ABSTRACT A physiologically‐based pharmacokinetic (PBPK) model of niraparib and its primary metabolite using a relevant virtual cancer population is reported here. A series of in vitro experiments using liver S9, microsomes, and hepatocytes with various inhibitors and recombinant supersomes demonstrated that niraparib is specifically metabolized by ...
Gareth J. Lewis +3 more
wiley +1 more source
Pharmaceutical Statistics, Volume 25, Issue 1, January/February 2026.ABSTRACT Bayesian predictive probabilities of success (PPoS) use interim trial data to calculate the probability of trial success. These quantities can be used to optimise trial size or to stop for futility. In this paper, we describe a simulation‐based approach to compute the PPoS for clinical trials with competing event data, for which no specific ...
Chiara Micoli +5 more
wiley +1 more source
Comparative study between the therapeutic effect of Remdesivir versus Hydroxychloroquine in Covid-19 hospitalized patients. [PDF]
, 2021 Maii Shams Eldeen +4 more
openalex +1 more source
A Rare Case of Pulmonary Alveolar Proteinosis Superimposed by Severe COVID‐19 Pneumonia: Case Report
Respirology Case Reports, Volume 14, Issue 1, January 2026.This report presents a rare case of pulmonary alveolar proteinosis (PAP) in a young male who subsequently developed COVID‐19. It highlights the critical importance of integrating clinical and radiological precision in diagnosing lung diseases with overlapping imaging features and underscores the rapid deterioration observed when PAP is complicated by ...
Zeinab El Mawla +2 more
wiley +1 more source
A study of effect of remdesivir on mortatlity and hospital stay of moderate to severe cases of COVID-19/ severe acute respiratory illness in North Karnataka region [PDF]
Al Ameen Journal of Medical Sciences, 2021 Background: As the epidemic that started at Wuhan spread globally many agents with antiviral activity were evaluated for the treatment of coronavirus disease. Many agents were claimed to be “Game changer” in the management of covid.
Habibulla D. Attar +4 more
doaj
Hydroxychloroquine and Remdesivir in COVID-19: A critical analysis of recent events [PDF]
, 2020 Amit Dang, BN Vallish, Sumit Dang
openalex +1 more source
Research in Pharmaceutical SciencesBackground and purpose: Coronavirus disease (COVID-19) is one ofthe greatest challenges ofthe twentieth century. Recently, in silico tools help to predict new inhibitors of SARS-CoV-2.
Maryam Abbasi +4 more
semanticscholar +1 more source