Results 61 to 70 of about 28,905 (311)
Review article, Aleksandra Hołubecka-Zielnica, Krzysztof Zielnica, Był taki czas… Pogranicze polsko-niemieckie (Syców – Kępno – Ostrzeszów).
Piotr Sroka
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Book review article: Buntownicy. Polskie lata 70.
Grzegorz Waligóra
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Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Sprawozdanie z panelu „Historia mówiona – etnografia – antropologia kulturowa: strategie, paralele, kontrasty” w ramach konferencji naukowej Jaka refleksja o kulturze jest dzisiaj potrzebna Europie?
Jolanta Kluba
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PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda +12 more
wiley +1 more source
Eugeniusz Szumiejko, Oppositionist’s Biography
In his account, Eugeniusz Szumiejko (born on Sept 9, 1946 in Wierobiejki), anti-communist opposition activist, recounts his childhood spent on the territories that were joined to the Soviet Union after the Second World War, resettlements and his later ...
Grzegorz Kowal
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‘Mediating Remembrance; Personalization and Celebrity in Television Remembrance’
In the period since the First World War both conflict and remembrance have been experienced at a personal level and through a range of media. This article discusses the growing significance of broadcast remembrance texts focusing upon three recent ...
Andrews, Maggie, MAGGIE ANDREWS
core +1 more source
Development of human monoclonal antibodies against TARM1 by yeast display
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe +5 more
wiley +1 more source

