Results 41 to 50 of about 492,944 (298)

Advancing Therapeutic Targets in IBD: Emerging Goals and Precision Medicine Approaches

Pharmaceuticals
Inflammatory bowel diseases (IBD) including Crohn’s disease (CD) and ulcerative colitis (UC) are chronic, relapsing conditions characterized by dysregulated immune responses and persistent intestinal inflammation.
Lucia Centanni, Clelia Cicerone, Fabrizio Fanizzi, Ferdinando D’Amico, Federica Furfaro, Alessandra Zilli, Tommaso Lorenzo Parigi, Laurent Peyrin-Biroulet, Silvio Danese, Mariangela Allocca   +9 more
doaj   +1 more source

ASSOCIATION BETWEEN CLINICAL MANIFESTATIONS AND ULTRASONIC SIGNS OF INFLAMMATION IN PATIENTS WITH RHEUMATOID ARTHRITIS

Научно-практическая ревматология, 2016
Rheumatoid arthritis (RA) is a systemic autoimmune rheumatic disease characterized by chronic inflammation of the synovial membrane and a wide range of extra-articular (systemic) manifestations.
O. G. Alekseeva, M. V. Severinova, N. V. Demidova, E. N. Aleksandrova, A. A. Novikov, E. L. Luchikhina, D. E. Karateev, A. V. Volkov, E. L. Nasonov   +8 more
doaj   +1 more source

Venetoclax‐Based Therapy as a Bridge to Hematopoietic Stem Cell Transplantation in Relapsed or Refractory Pediatric Acute Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Relapsed and/or refractory (R/R) pediatric acute leukemia carries a dismal prognosis, largely driven by chemoresistance to conventional salvage therapy. The BH3‐mimetic venetoclax, combined with chemotherapy or hypomethylating agents, has demonstrated efficacy in small clinical trials.
Katherine S. Colman, Deborah Meyran, Vajiranee Malalasekera, Heather Weerdenburg, Janine Campbell, Rachel Conyers, Stacie Wang, Hannah Walker, Seong Lin Khaw, Diane Hanna   +9 more
wiley   +1 more source

Facts and myths about use of esketamine for treatment-resistant depression: a narrative clinical review

Frontiers in Psychiatry
Introduction and aimsTreatment-resistant depression (TRD) occurs when at least two different antidepressants, taken at the right dosage, for adequate period of time and with continuity, fail to give positive clinical effects. Esketamine, the S-enantiomer
Matteo Di Vincenzo, Vassilis Martiadis, Bianca Della Rocca, Eleonora Arsenio, Andrea D’Arpa, Antonio Volpicelli, Mario Luciano, Gaia Sampogna, Andrea Fiorillo   +8 more
doaj   +1 more source

POSSIBILITIES FOR PRESERVING THE RESULTS OF TREATMENT IN PATIENTS WITH ACTIVE RHEUMATOID ARTHRITIS AFTER DOSE REDUCTION AND/OR DISCONTINUATION OF BIOLOGICAL AGENTS: A REMARCA STUDY

Современная ревматология, 2016
Russian and international clinical recommendations postulate the possibility of withdrawal of biological agents in patients with rheumatoid arthritis (RA) after the achievement of clinical remission.
E. L. Luchikhina, D. E. Karateev, N. V. Demidova, G. S. Gridneva, G. V. Lukina, M. A. Kanonirova, Yu. V. Muravyev, K. A. Kasumova, E. N. Aleksandrova, A. А. Novikov, A. S. Avdeeva   +10 more
doaj   +1 more source

Prevalence and Predictors of Remission and Sustained Remission in Patients with Rheumatoid Arthritis from the United Arab Emirates: A Two-Year Prospective Study

, 2023
Jamal Al-Saleh,1 Ahlam Almarzooqi,2 Ahmed A Negm1 1Rheumatology, Dubai Hospital, Dubai Health Authority, Dubai, United Arab Emirates; 2Rheumatology, Al Qassimi Hospital, Emirates Health Services, Sharjah, United Arab EmiratesCorrespondence: Jamal Al ...
Almarzooqi A, Negm AA, Al-Saleh J
core  

Biphasic Clinical Course of Pediatric Cytomegalovirus‐Associated Immune Thrombocytopenia: Early Poor Treatment Response but Favorable Long‐Term Outcomes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Cytomegalovirus (CMV) is a recognized trigger of immune thrombocytopenia (ITP); however, its incidence and impact on disease course in children remain controversial. Therefore, we aimed to characterize the clinical course of pediatric patients with CMV‐associated ITP.
Oded Gilad, Ohad Atia, Osama Tanous, Dafna Brik Simon, Michal Dvori, Miriam Cohen, Tracie A. Goldberg, Efraim Bilavsky, Joanne Yacobovich, Orna Steinberg‐Shemer   +9 more
wiley   +1 more source

Transsphenoidal Surgery of Corticotroph Adenomas With Cavernous Sinus Invasion: Results in a Series of 86 Consecutive Patients

Frontiers in Oncology, 2022
ObjectiveTranssphenoidal surgery (TSS) is the first-line treatment for corticotroph adenomas. Although most corticotroph adenomas are noninvasive microadenomas, a small subset of them invading cavernous sinus (CS) is notoriously difficult to manage.
Congxin Dai, Ming Feng, Lin Lu, Bowen Sun, Yanghua Fan, Xinjie Bao, Yong Yao, Kan Deng, Renzhi Wang, Jun Kang   +9 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Proportion and predictors of remission and recovery in first-episode psychosis: Systematic review and meta-analysis [PDF]

, 2021
[EN] Background To determine the proportion of patients in symptomatic remission and recovery following a first-episode of psychosis (FEP). Methods A multistep literature search using the Web of Science database, Cochrane Central Register of Reviews ...
Mancebo Fernández, Gonzalo, Gil, Patxi, Richter, Anja, Fusar-Poli, Paolo, Catalán Alcántara, Ana, Vaquerizo Serrano, Julio, Pedruzo, Borja, Salazar de Pablo, Gonzalo, Gil López, Patxi, Catalan, Ana, McGuire, Philip, Vaquerizo-Serrano, Julio, Mancebo, Gonzalo, González Torres, Miguel Ángel, Solmi, Marco, González-Torres, Miguel Á, Aymerich, Claudia   +16 more
core   +1 more source