Results 211 to 220 of about 1,176,116 (301)

Integrating research and surveillance to mitigate zoonotic disease risk in indigenous communities: Insights from an expert group meeting in Amazonas, Peru. [PDF]

PLoS Negl Trop Dis
Pérez JG, Ribeiro R, Bergner L, Mollentze N, Bustamante-Chauca P, Gonzales L, Rivera RC, Bernal M, Osorio VL, Recuenco S, Ghersi BM, Colchao-Claux P, Soldán-Villarreal L, Bardales W, Rodríguez-Chávez J, Quintana JLM, Tello C, Tapia-Limonchi R, Streicker DG, Chenet SM.   +19 more
europepmc   +1 more source

Adaptive imatinib regimens can mitigate cumulative toxicity while sustaining hemodynamic benefit: A model‐based simulation of the positioning imatinib for pulmonary arterial hypertension trial

British Journal of Clinical Pharmacology, EarlyView.
ABSTRACT Aims Imatinib improves hemodynamics in pulmonary arterial hypertension (PAH), but dose‐dependent toxicity has limited its clinical development. We aimed to quantify the dose–efficacy–toxicity relationship and evaluate alternative dosing strategies using data from the PIPAH trial.
Medhat M. Said, Robert B. de Mooij, Dian Jiao, Reitze J. Ovelgonne, Rami Biram, Juan Delgado‐SanMartin, Alexander M. K. Rothman, Sofia S. Villar, Andreas A. Roussakis, Jurjan Aman, Ron A. A. Mathôt, Eleonora L. Swart, Martin R. Wilkins, Imke H. Bartelink   +13 more
wiley   +1 more source

When precaution outlasts evidence: reconsidering blood collection in French Guiana. [PDF]

Lancet Reg Health Am
Epelboin L, Nacher M, Djossou F, Hermine O.   +3 more
europepmc   +1 more source

Analysis of clinical investigation (device) initial submissions received by the Medicines and Healthcare products Regulatory Agency between January 2022 and December 2025

British Journal of Clinical Pharmacology, EarlyView.
Aims This study aimed to analyse clinical investigation‐device initial submissions received by the MHRA between January 2022 and December 2025. Methods Data on submissions were extracted from the clinical investigations unit data bank; software as medical devices were not included. The predefined primary end‐point was submission type.
Andrea Manfrin, Mark Grumbridge, Daniel Hill, Crina Cacou, Graham Warren, James Pound, Jacob George, Alejandro F. Frangi   +7 more
wiley   +1 more source

Implementing point-of-care ultrasound (PoCUS) in UK primary care: current and future perspectives. [PDF]

Br J Gen Pract
Poppleton A, Pursglove L, Mostafa A, ElNaggar I, Jadeja J, Daza-Ramirez P.   +5 more
europepmc   +1 more source

‘In a small school, it's just capacity all of the time’: Delivery and experiences of a national early career teacher development initiative across diverse school settings in England

British Educational Research Journal, EarlyView.
Abstract Effective early career support is associated with a variety of professional and personal benefits for teachers and their schools. However, research indicates that the contextual features of schools, such as their size and geographic location, influence the support that new teachers receive.
Ellen Turner, Alexandra Bates, David Aldridge, Roisin Ellison, Grace Healy, Jen Knowles, Katy Micklewright, Grace Stevens, Calum Davey   +8 more
wiley   +1 more source

Economic evaluation of the TriageHF Plus clinical pathway for device-based remote monitoring in heart failure. [PDF]

Heart
Ahmed FZ, Harwood R, Lanctin D, Leonard C, Medland S, Afonso D, Mealing S, Weldon T, Blunt C, Campbell NG, Taylor JK.   +10 more
europepmc   +1 more source

Extracellular Vesicles‐Based Biological Macromolecule Delivery Systems: Biogenesis, Characterization, and Emerging Clinical Applications

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are nanoscale membrane‐bound structures that play a pivotal role in intercellular communication by transporting bioactive molecules, including proteins, lipids, nucleic acids, and organelles, between cells. Originating from the endosomal pathway, EVs reflect the physiological and pathological status of their parent
Emine İncilay Torunoğlu, Zeynep Betül Sarı, Muhammed Emin Sarı, Erdi Can Aytar   +3 more
wiley   +1 more source

Assessing Acceptance and Intention to Use of Home Telemonitoring Among Patients with Liver Cirrhosis: Development and Initial Psychometric Validation of a TAM-Based Questionnaire. [PDF]

Diagnostics (Basel)
Marin RC, Păunescu H, Muntean C, Balaban DV, Coman LI, Radu N, Jinga M, Coman OA.   +7 more
europepmc   +1 more source

Process Analytical Technology (PAT) for Continuous Purification of mRNA via Precipitation and Tangential Flow Filtration

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Continuous downstream processing of messenger ribonucleic acid (mRNA) therapeutics requires purification strategies that are scalable, robust, and capable of removing product‐ and process‐related impurities from in vitro transcription mixtures.
Rajan R. Bhawnani, Maria del Carme Pons Royo, Rohan Kadambi, Andrew Hatas, Steve Burcat, Tyler Arnold, Hasan Al‐Mahayni, Richard D. Braatz, Allan S. Myerson   +8 more
wiley   +1 more source