Results 41 to 50 of about 104,811 (269)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Analyzing coastal dynamics by means of multi-sensor satellite imagery at the East Frisian Island of Langeoog, Germany

Scientific Reports
Monitoring coastal dynamics is critical for the effective protection of coastal environments. Satellite remote sensing data offers significant potential to support this monitoring while also addressing the considerable challenges posed by the rapidly ...
Julia Holzner, Günter Strunz, Sandro Martinis, Simon Plank   +3 more
doaj   +1 more source

Evaluation of Lossy Compressed Mosaic for SPOT-6/7 Remote Sensing Data in SPACeMAP

JOIV: International Journal on Informatics Visualization, 2021
SPACeMAP is a remote-sensing data portal system owned by LAPAN used to distribute mosaic data of Medium-Resolution to Very-High-Resolution for Provincial Governments.
Agnes S Payani, Siti D Wahyuningsih, Gusti D Yudha, Nico Cendiana, Hanna Afida, Steward Augusto   +5 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Validity of a Wearable Digital Insole for Assessing Gait ON and OFF in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Gait impairment is a distinctive symptom of Parkinson's disease that negatively impact mobility. We assessed the validity of wearable digital insoles against a validated reference gait analysis system for measuring select gait characteristics in patients with Parkinson's disease. Methods A comparative analysis between digital insoles
Deborah A. Hall, Kimberly Kwei, Rolando J. Acosta, Bharatkumar Koyani, Erin Robertson, Pratyush Rai, Roland Barge, Emily Timm, Nicollette L. Purcell, Natasha Desai, Dhanesh Patel, Ana‐Maria Visoiu‐Knapp, Samuel Stuart, Rinol Alaj, Matthew F. Wipperman, Oren Levy, Joan A. O'Keefe   +16 more
wiley   +1 more source

Normal‐Appearing White Matter Injury Mediates Chronic Deep Venous Hypoxia and Disease Progression in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore how cerebral hypoxia and Normal‐Appearing White Matter (NAWM) integrity affect MS lesion burden and clinical course. Methods Seventy‐nine MS patients, including 13 clinically isolated syndrome (CIS) patients and 66 relapsing–remitting multiple sclerosis (RRMS) patients, and 44 healthy controls (HCs) were recruited from ...
Xinli Wang, Huiying Wang, Zhizheng Zhuo, Ai Guo, Ke Lv, Decai Tian, Chao Chai, Yunyun Duan, Shuang Xia   +8 more
wiley   +1 more source

Web-based rapid mapping with earth observation and geospatial data supports flood response in Southern Germany in 2024

Discover Applied Sciences
With the progression of climate change, Central Europe faces an increasing risk of extreme weather events, particularly floods and wildfires. One of the latest events took place in June 2024, when continuous rainfall in southern Germany caused water ...
Anne Schneibel, Magdalena Halbgewachs, Sandro Groth, Veronika Gstaiger, Monika Gähler   +4 more
doaj   +1 more source

S1S2-Water: A Global Dataset for Semantic Segmentation of Water Bodies From Sentinel- 1 and Sentinel-2 Satellite Images

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
This study introduces the S1S2-Water dataset—a global reference dataset for training, validation, and testing of convolutional neural networks (CNNs) for semantic segmentation of surface water bodies in publicly available Sentinel-1 and Sentinel-2
Marc Wieland, Florian Fichtner, Sandro Martinis, Sandro Groth, Christian Krullikowski, Simon Plank, Mahdi Motagh   +6 more
doaj   +1 more source

Systematic Evaluation of Four Satellite AOD Datasets for Estimating PM_2.5 Using a Random Forest Approach

Remote Sensing, 2023
The latest epidemiological studies have revealed that the adverse health effects of PM2.5 have impacts beyond respiratory and cardio-vascular diseases and also affect the development of the brain and metabolic diseases.
Jana Handschuh, Thilo Erbertseder, Frank Baier   +2 more
doaj   +1 more source

The Role of Calcitonin Gene‐Related Peptide in High‐Altitude Headache: A Prospective Field Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective High‐altitude headache (HAH) is a common neurological condition associated with rapid ascent to high altitude. The pathophysiological mechanisms underlying HAH remain incompletely understood. Calcitonin gene‐related peptide (CGRP), a neuropeptide implicated in migraine pathophysiology, may play a key role in the pathophysiology of ...
Roman Schniepp, Ludwig Karrasch, Helena Breitenstein, Andreas Straube, Katharina Kamm   +4 more
wiley   +1 more source