Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
A Removable 3D-Printed Protective Cap for Chronic Cranial Implants in Rhesus Macaques (<i>Macaca mulatta</i>): A Descriptive Case Series and Technical Refinement. [PDF]
Animals (Basel)Moore RD +3 more
europepmc +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Macroporous Poly(hydroxyethyl methacrylate) Hydrogels as Removable Antibiotic-Capture Liners for Endotracheal Tubes Designed to Prevent Ventilator-Associated Pneumonia. [PDF]
Polymers (Basel)Jones DS +4 more
europepmc +1 more source
Molecular Oncology, EarlyView.Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani +9 more
wiley +1 more source
A Digitally Guided, Single-Visit Workflow for Miniscrew-Assisted Rapid Palatal Expansion: The YOM Technique. [PDF]
CureusAlshamly MY, A Abdelhamid MM, Marei MA.
europepmc +1 more source
Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
Orthodontic Treatment Need and Short-Term Oral Hygiene Assessment in Children Undergoing Different Early Orthodontic Treatments. [PDF]
Children (Basel)Atmaca N, Tozlu M, Peker S, Kargül B.
europepmc +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Management of Persistent Thumb-Sucking Habit Using a Modified Thumb Guard Appliance: A Case Report. [PDF]
CureusSudrik SS +4 more
europepmc +1 more source