Results 141 to 150 of about 7,982,343 (363)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Removal of Reactive Black 5 (RB5) Dye from Aquatic Solution by Using of Adsorption onto Synthesized Sodium Alginate Magnetic Beads [PDF]

Background and Objectives: Industrial wastewater included the dyes one of the important sources of environmental pollution, that founded in loom wastewater which are harmful for human health and environment.
سمرقندی, محمدرضا, شکوهی, رضا, شیرزاد سیبنی, مهدی, واحدی, حوریه, پورفرضی, فرهاد   +4 more
core  

Modeling Virus Transport and Removal during Storage and Recovery in Heterogeneous Aquifers [PDF]

, 2019
A quantitative understanding of virus removal during aquifer storage and recovery (ASR) in physically and geochemically heterogeneous aquifers is needed to accurately assess human health risks from viral infections.
Bradford, Scott A, Hocking, Mark, Sasidharan, Salini, Simunek, Jiri, Tazehkand, Sara S, Torkzaban, Saeed   +5 more
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Recommendations of the panels: Panel on ozone destruction techniques [PDF]

Catalyst materials to reduce weight, size, and cost of the ozone removal device were developed. Catalyst bed lifetime, competitive reactivity contaminants in the inlet air on the catalyst bed efficiency for ozone removal, and the kinetics and mechanism ...
Wydeven, T.
core   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Enhancing phosphorus removal: the impact of alkaline environment in eutrophic water systems

Environmental Research Communications
Excessive phosphorus input leads to poor water quality and eutrophication. However, limited research has directly explored the influence of pH on phosphorous in actual aquatic systems.
Yi Zhang, Benhong Liu, Lei Liu, Jue Wang
doaj   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Quantifying Influencing Factors of Dioxin Removal in Fly Ash Pyrolysis Through Meta-Analysis and Structural Equation Modeling

Toxics
The treatment of polychlorinated dibenzodioxins and polychlorinated dibenzofurans (PCDD/Fs) in incineration fly ash presents a significant challenge in solid hazardous waste management.
Tao He, Shihan Tan, Qi Su, Feifei Chen, Chenlei Xie, Yuchi Zhong, Shuai Zhang, Jiafeng Ding   +7 more
doaj   +1 more source