Results 251 to 260 of about 324,431 (365)

An Engineered PfAgo with Wide Catalytic Temperature Range and Substrate Spectrum

Advanced Science, EarlyView.
This work presents a strategy for engineering thermophilic Ago proteins to obtain wide catalytic temperature range and broad substrate spectrum. This strategy is applied to engineer PfAgo and TtdAgo, and the biochemical properties of the engineered PfAgo are systematically characterized. The study further elucidates the structural differences involved.
Longyu Wang, Xiaochen Xie, Fuyong Huang, Qiang Wei, Tianxin Cai, Na Yu, Shi Chen, Fei Wang, Wanping Chen, Chin‐yu Chen, Chunhua Li, Lixin Ma   +11 more
wiley   +1 more source

A narrative review of pharmacy workforce challenges in Indonesia. [PDF]

Hum Resour Health
Meilianti S, Smith F, Fauziyyah AN, Masyitah N, Kristianto F, Ernawati DK, Naya R, Bates I.   +7 more
europepmc   +1 more source

International–local remuneration differences across six countries: Do they undermine poverty reduction work? [PDF]

, 2010
Stuart C. Carr, Ishbel McWha, Malcolm MacLachlan, Adrian Furnham   +3 more
openalex   +1 more source

LEDGF Binds H3R17me2a Promoting De Novo Nucleotide Biosynthesis in SETD2 Mutant Clear Cell Renal Cell Carcinoma

Advanced Science, EarlyView.
In SETD2‐mutant ccRCC, the original LEDGF recognition of the H3K36me3 regulatory axis no longer exists. LEDGF interacts with CARM1‐dependent H3R17me2a regulating the transcription of key enzymes in the de novo synthesis pathway. The abnormally elevated LEDGF leads to the accumulation of purine nucleotides in SETD2‐mutant ccRCC, thereby satisfying the ...
Yuwei Zhang, Yuhua Zhou, Yuezhou Zhang, Jing Lv, Yang Shen, Dong Zhang, Bo Liu, Wei Zhao, Junyi Ju, Qingyi Zhu, Ke Wang, Ninghan Feng   +11 more
wiley   +1 more source

'I Think That Is a Big Step From Here to There': Exploring the Views of Service Providers About Delivering Drug- and Alcohol-Related Health Services to Aboriginal People in Rural New South Wales. [PDF]

Drug Alcohol Rev
Wallace R, Clay S, Shakeshaft A, Farnbach S.   +3 more
europepmc   +1 more source

INSTITUTIONAL TRANSFORMATIONS IN THE INFORMATIONAL SPHERE OF CAPITAL MARKET AND THE EFFECTIVENESS OF REMUNERATING MANAGERS IN STOCK EXCHANGE COMPANIES

, 2006
Jolanta Szapiel
openalex   +2 more sources

MTCH2 Deficiency Promotes E2F4/TFRC‐Mediated Ferroptosis and Sensitizes Colorectal Cancer Liver Metastasis to Sorafenib

Advanced Science, EarlyView.
This study identifies MTCH2 as a crucial regulator of ferroptosis in colorectal cancer (CRC) progression. High expression of MTCH2 is correlated with poor prognosis in CRC patients. Furthermore, MTCH2 depletion induces ferroptosis to suppress CRC liver metastasis via the E2F4/TFRC axis and sensitizes tumors to sorafenib treatment, supporting MTCH2 as a
Pu Xing, Jiangbo Chen, Hao Hao, Xiaowen Qiao, Xinying Yang, Kai Weng, Jie Chen, Lin Song, Tianqi Liu, Yifan Hou, Tongkun Song, Yumeng Ran, Bo Chen, Hong Yang, Wei Zhao, Zaozao Wang, Jiabo Di, Beihai Jiang, Xiangqian Su   +18 more
wiley   +1 more source

Platelet Transfusions: Current Practices and Emerging Alternatives in the United States. [PDF]

Life (Basel)
Friedman M, Costa V, Rafiee B, Hilbert T, Jafri M, Wu DW.   +5 more
europepmc   +1 more source

THE REPRODUCTION RIGHT AND COLLECTIVE MANAGEMENT IN THE CONTEXT OF THE INFORMATION SOCIETY (The right to remuneration for private copy; The ring tones and the Internet)

, 2006
MUNKÁCSI Peter
openalex   +1 more source

Identifying Myeloid‐Derived Suppressor Cells and Lipocalin‐2 as Therapeutic Targets for Intervertebral Disc Degeneration

Advanced Science, EarlyView.
Inflammatory dysregulation drives intervertebral disc degeneration via stage‐dependent immune cellular dynamics. Single‐cell transcriptomics and genetic risk mapping revealed a shift from LCN2high myeloid‐derived suppressor cells maintaining disc repair in early stages to IL1B+ macrophage‐dominated pathology in advanced disease.
Changmeng Zhang, Haoyun Li, Hongfei Wang, Liangyu Shi, Ying Shing Chan, Yu Wang, Graham Ka Hon Shea   +6 more
wiley   +1 more source