Results 251 to 260 of about 324,431 (365)
An Engineered PfAgo with Wide Catalytic Temperature Range and Substrate Spectrum
This work presents a strategy for engineering thermophilic Ago proteins to obtain wide catalytic temperature range and broad substrate spectrum. This strategy is applied to engineer PfAgo and TtdAgo, and the biochemical properties of the engineered PfAgo are systematically characterized. The study further elucidates the structural differences involved.
Longyu Wang+11 more
wiley +1 more source
A narrative review of pharmacy workforce challenges in Indonesia. [PDF]
Meilianti S+7 more
europepmc +1 more source
International–local remuneration differences across six countries: Do they undermine poverty reduction work? [PDF]
Stuart C. Carr+3 more
openalex +1 more source
In SETD2‐mutant ccRCC, the original LEDGF recognition of the H3K36me3 regulatory axis no longer exists. LEDGF interacts with CARM1‐dependent H3R17me2a regulating the transcription of key enzymes in the de novo synthesis pathway. The abnormally elevated LEDGF leads to the accumulation of purine nucleotides in SETD2‐mutant ccRCC, thereby satisfying the ...
Yuwei Zhang+11 more
wiley +1 more source
'I Think That Is a Big Step From Here to There': Exploring the Views of Service Providers About Delivering Drug- and Alcohol-Related Health Services to Aboriginal People in Rural New South Wales. [PDF]
Wallace R+3 more
europepmc +1 more source
This study identifies MTCH2 as a crucial regulator of ferroptosis in colorectal cancer (CRC) progression. High expression of MTCH2 is correlated with poor prognosis in CRC patients. Furthermore, MTCH2 depletion induces ferroptosis to suppress CRC liver metastasis via the E2F4/TFRC axis and sensitizes tumors to sorafenib treatment, supporting MTCH2 as a
Pu Xing+18 more
wiley +1 more source
Platelet Transfusions: Current Practices and Emerging Alternatives in the United States. [PDF]
Friedman M+5 more
europepmc +1 more source
Inflammatory dysregulation drives intervertebral disc degeneration via stage‐dependent immune cellular dynamics. Single‐cell transcriptomics and genetic risk mapping revealed a shift from LCN2high myeloid‐derived suppressor cells maintaining disc repair in early stages to IL1B+ macrophage‐dominated pathology in advanced disease.
Changmeng Zhang+6 more
wiley +1 more source