Results 171 to 180 of about 571,370 (304)

Genetic and Functional Evidence Links Germline Biallelic Inactivating Variants in WWOX to Histological Mixed‐Type Thyroid Cancer

Advanced Science, EarlyView.
The role of germline WWOX loss‐of‐function variants in oncogenesis has remained poorly characterized. This study provides the first comprehensive genetic and functional evidence that such variants promote tumorigenesis through the disruption of multiple tumor‐suppressive mechanisms.
Xiaopeng Zhang, Jian Qi, Jialiang Wang, Zhipeng Wang, Yongguang Wang, Zongtao Hu, Ao Xu, Bo Hong, Hongzhi Wang   +8 more
wiley   +1 more source

Effects of levosimendan on renal blood flow and glomerular filtration in patients with acute kidney injury after cardiac surgery: a double blind, randomized placebo-controlled study. [PDF]

Crit Care, 2021
Tholén M, Ricksten SE, Lannemyr L.
europepmc   +1 more source

Drug-induced changes in renal hippurate clearance as a measure of renal blood flow

, 1995
C. Antoinette Visscher, Dick de Zeeuw, Paul E. de Jong, Wim J. Sluiter, Roel M. Huisman   +4 more
openalex   +1 more source

Single‐Cell Transcriptome Atlas Reveals the Underlying Mechanism of Kynurenic Acid in the Regulation of Tumor Immune Microenvironment in Glioblastoma

Advanced Science, EarlyView.
KYNA regulates the tumor immune microenvironment in glioblastoma. KYNA reprograms the balance between T cell exhaustion and activation to suppress glioblastoma progression through inhibiting exhaustion‐associated markers (such as PD‐1, LAG3, and TOX) and enhancing immune activation and cytotoxicity markers including granzymes GZMA and GZMB.
Di Chen, Liming Sun, Jiajun Chen, Zi Ye, Xuqiang Zhu, Hongjiang Li, Lixin Wu, Guohua Zhao, Qinghao Zhang, Guangyi Jiang, Yuchen Ji, Yake Xue, Hongwei Li, Ruokun Chen, Hongwei Zheng, Rong Zeng, Dongming Yan, Yong Zhang, Xueyuan Li, Jing Yan   +19 more
wiley   +1 more source

Results of Surgical Repair of Hilar Renal Artery Aneurysm to Preserve Renal Blood Flow. [PDF]

Ann Vasc Dis, 2020
Kawase T, Inoue Y, Matsuo J, Omura A, Seike Y, Uehara K, Sasaki H, Matsuda H.   +7 more
europepmc   +1 more source

Nanofluid‐Enhanced Laser Lithotripsy Using Conducting Polymer Nanoparticles

Advanced Science, EarlyView.
Incorporating polymeric nanoparticles, PEDOT:PSS, with a high near‐infrared absorption coefficient into the fluid significantly enhances the dusting efficiency of Ho:YAG laser lithotripsy for kidney stone treatment. This approach, which leverages the control of light‐matter interactions, integrates seamlessly with the current laser lithotripsy workflow.
Qingsong Fan, Junqin Chen, Arpit Mishra, Aaron Stewart, Faisal Anees, Ting‐Hsuan Chen, Judith Dominguez, Christine Payne, Michael E. Lipkin, Pei Zhong, Po‐Chun Hsu   +10 more
wiley   +1 more source

Midkine‐Mediated Microglia Activation after Renal Injury Promotes Cognitive Impairment Following Ischemic Renal Injury

Advanced Science, EarlyView.
The mechanism of secondary cognitive impairment following AKI. When renal ischemic injury progresses to fibrosis, renal fibroblasts and damaged tubular cells secrete MDK, which circulates through the bloodstream, crosses the damaged BBB, and accumulates in the hippocampus tissue (an area crucial for learning and memory).
Li Lu, Bixiao Liu, Yu Yang, Tao Meng, Yuanyuan Chang, Yao Peng, Jia Guo, Zhuqing Wang, Hongqian Guo, Liuhua Zhou, Xiaozhi Zhao   +10 more
wiley   +1 more source

Targeted Expansion of Treg Cells to Induce Immune Tolerance after Kidney Transplantation

Advanced Science, EarlyView.
A dual‐targeting nanoparticle platform that selectively engages graft stromal cells via CD248 receptors while employing kidney‐ specific promoters (NPHS2) to drive localized IL‐ 2/TGF‐βexpression is developed. This approach achieves three therapeutic objectives:1) intragraft Treg polarization without systemic cytokine exposure;2) reduced dependence on ...
Tong Lu, Hongtao Song, Limin He, Zhihao Hu, Yu Li, Chao Xu, Shaojie Liu, Jun Jiang, Yike Zhou, Zhengxuan Li, Zeyu Li, Keying Zhang, Shuaijun Ma, Ruochen Qi, Shichao Han, Changhong Shi, Weihong Wen, Donghui Han, Weijun Qin   +18 more
wiley   +1 more source

Prediction of postoperative renal function by measuring renal blood flow using Doppler sonography in kidney donors [PDF]

, 2003
T Ushiyama, Miwa Aoki, Tatsuya Takayama, Nobuo Tsuru, Hiroshi Furuse, Akira Ishikawa, Susumu Kageyama, Kazuo Suzuki, Kazuyo Fujita   +8 more
openalex   +1 more source

Null mutation of the p67phox subunit of NOX2 permits compensatory changes in renal blood flow during the development of salt-sensitive hypertension in SS rats. [PDF]

Am J Physiol Renal Physiol
Evans LC, Dayton A, Kurth T, Anidu BS, Polichnowski AJ, Cowley AW.   +5 more
europepmc   +1 more source