Results 151 to 160 of about 575,729 (357)

Folic Acid‐Modified Ginger‐Derived Exosome‐Like Nanoparticles Co‐Delivering Sunitinib Suppress Renal Cell Carcinoma via PI3K‐Akt Pathway Inhibition, P‐gp Downregulation, and Macrophage Reprogramming

Advanced Science, EarlyView.
FPD‐GELNs co‐deliver Su and bioactive components. This active‐passive dual‐targeting strategy suppresses the progression of RCC through the following mechanisms: 1) inhibition of the PI3K‐Akt signaling pathway; 2) downregulation of ABCB1/P‐gp to enhance the chemosensitivity of RCC to Su; and 3) reprogramming of macrophages toward M1 polarization and ...
Haoyu Xu, Daixing Hu, Shixue Liu, Lei Yang, Junwu Li, Yuanyuan Bai, Guozhi Zhao, Wei Tang, Li Jiang   +8 more
wiley   +1 more source

Ipsilateral synchronous renal pelvic transitional cell carcinoma and renal cell carcinoma: a case report and review of the literature [PDF]

, 1991
腎盂尿管と腎実質の重複腫瘍は稀であり, 現在までに本邦では27例が報告されているにすぎない.肉眼的血尿を主訴として受診し精査の結果, 腎盂移行上皮癌と腎細胞癌の同時同側性重複腫瘍と診断された1例(75歳男)を経験したA case of ipsilateral transitional cell carcinoma of left renal pelvis and left-renal cell carcinoma is presented.
原田, 吉將, 栗山, 学, 武田, 明久, 永井, 司, 河田, 幸道, 篠田, 徳郎, 谷口, 光宏, 高橋, 義人   +7 more
core  

An epithelial-mesenchymal transition-Related Long Non-Coding RNA signature to predict overall survival and immune microenvironment in Kidney Renal Clear Cell Carcinoma

, 2021
Yongbiao Cheng, Sen Li, Youpeng Zhang, Zhaohui Zhu, Ning Zhao   +4 more
openalex   +1 more source

PBRM1 Deficiency Reshapes an Immune Suppressive Microenvironment Through Epigenetic Tuning of PBRM1‐KDM5C‐IL6 Axis in ccRCC

Advanced Science, EarlyView.
PBRM1 ranks as the second most commonly mutated gene in ccRCC. This study reveals that PBRM1 loss promotes an immunosuppressive microenvironment by elevating M2 TAMs via the KDM5C–IL‐6 axis. These M2 TAMs, along with CAFs, form a barrier that excludes CD8+ T cells. Targeting IL‐6 synergizes with anti‐PD1 therapy, offering a promising strategy for PBRM1‐
Wenjiao Xia, Hongru Wang, Yu Dong, Zitong Yang, Yiyang Zhou, Zhinan Xia, Qinchen Li, Liangliang Ren, Yichun Zheng, Junliang Yan, Dongmei Ma, Zhi Chen, Xingang Cui, Guixin Zhu, Cheng Zhang   +14 more
wiley   +1 more source

Prognostic significance of primary-tumor extension, stage and grade of nuclear differentiation in patients with renal cell carcinoma [PDF]

, 2002
Surgery remains the preferred therapy for renal cell carcinoma. The various adjunctive or complementary therapies currently yield disappointing results. Identifying reliable prognostic factors could help in selecting patients most likely to benefit from ...
Barbarosos A, Bolognese A., Bononi M, D'Andrea N, De Cesare A, FIORE, ELEONORA, Galati G, Izzo L   +7 more
core  

Prediction for early progression of metastatic renal cell carcinoma treated with first-line tyrosine kinase inhibitors

, 2020
Jun Teishima, T. Hayashi, Seiya Inoue, Yohei Sekino, Shinsuke Fujii, Kenichiro Ikeda, Keisuke Goto, Akio Matsubara   +7 more
openalex   +1 more source

GLUL Confers Perivascular Cancer‐Associated Fibroblasts With Pro‐Angiogenic Capacity to Promote Glioma Progression

Advanced Science, EarlyView.
Schematic illustration of the proposed model. Primary CAFs are isolated from fresh human GBM specimens according to established protocols. GLUL is essential for pro‐angiogenic capacity of CAFs through its impact on the PI3K/AKT pathway. GLUL enhances the pro‐angiogenic capacity of CAFs, driving aberrant tumor vasculature that fuels tumor growth ...
Qing Zhang, Yida Liu, Zhi Zhang, Yang Wang, Fusheng Liu   +4 more
wiley   +1 more source

Partial nephrectomy for presumed renal cell carcinoma: Incidence, predictors, and perioperative outcomes of benign lesions [PDF]

, 2017
Bauman, Tyler M, Figenshau, R. Sherburne, Knight, Brent A, Potretzke, Aaron M, Vetter, Joel M, Wright, Alec J   +5 more
core   +2 more sources

Management of metastatic renal cell carcinoma in patients with poor prognosis

, 2010
Michael Atkins, Michael Atkins, McDermott, Andrea J. Bullock   +3 more
openalex   +1 more source

Low Lymphocyte-to-Monocyte Ratio Is the Potential Indicator of Worse Overall Survival in Patients with Renal Cell Carcinoma and Venous Tumor Thrombus [PDF]

, 2021
Łukasz Zapała, Michał Kunc, Sumit Sharma, Wojciech Biernat, Piotr Radziszewski   +4 more
openalex   +1 more source