Results 151 to 160 of about 577,818 (354)

ERM Inhibition Confers Ferroptosis Resistance through ROS‐Induced NRF2 Signaling

Advanced Science, EarlyView.
ERM inhibition disrupts ERM‐actin interactions, elevating ROS and triggering KEAP1 degradation, which stabilizes and activates NRF2. Nuclear NRF2 induces cytoprotective genes, notably HMOX1, enhancing redox buffering and suppressing lipid peroxidation to resist erastin‐induced ferroptosis.
Menghao Qiao, Liqun Zhou, Minhua Zhou, Yu Fang, Haiying Mai, Lingbo Cao, Kun Xu, Yuan Sang, Minyi Chen, Jiewei Huang, Peiyi Huang, Zhipeng Yan, Chao Wang, Zhangshuai Dai, Dichun Huang, Ronghan He, Lijuan Pang, Yunmiao Guo, Ting Gang Chew, Junqi Huang   +19 more
wiley   +1 more source

Multiple tumor suppressors regulate a HIF-dependent negative feedback loop via ISGF3 in human clear cell renal cancer. [PDF]

, 2018
Whereas VHL inactivation is a primary event in clear cell renal cell carcinoma (ccRCC), the precise mechanism(s) of how this interacts with the secondary mutations in tumor suppressor genes, including PBRM1, KDM5C/JARID1C, SETD2, and/or BAP1, remains ...
Cai, Weijia, Cai, Wesley L., Cho, Eun-Ah, Dulaimi, Essel, Jagannathan, Geetha, Jiang, Wei, Langbein, Lauren, Liao, Lili, Liu, Zongzhi Z., Na, Jie, Niu, Xiaohua, Peiper, Stephen C., Stark, George R., Sun, Jianxin, Testa, Joseph R., Uzzo, Robert G., Wang, Yuxin, Xu, Yaomin, Yan, Qin, Yang, Haifeng, Zhong, Zhijiu   +20 more
core   +1 more source

The platelet-to-lymphocyte ratio as a significant prognostic factor to predict survival outcomes in patients with synchronous metastatic renal cell carcinoma

, 2020
Hyeong Dong Yuk, Minyong Kang, Eu Chang Hwang, Jae Young Park, Chang Wook Jeong, Cheryn Song, Seong Il Seo, Seok‐Soo Byun, Cheol Kwak, Sung‐Hoo Hong, Jinsoo Chung, Hakmin Lee, the Korean Renal Cancer Study (KRoCS) Group   +12 more
openalex   +1 more source

Renal Cell Carcinoma of the Kidney with Synchronous Ipsilateral Transitional Cell Carcinoma of the Renal Pelvis [PDF]

, 2013
Doğan Atılgan, Nıhat Uluocak, Bekir Süha Parlaktaş   +2 more
openalex   +1 more source

Cancer Stem Cells Shift Metabolite Acetyl‐Coenzyme A to Abrogate the Differentiation of CD103+ T Cells

Advanced Science, EarlyView.
Lei et al. demonstrate that cancer stem cells (CSCs) play a pivotal role in impairing the differentiation of CD103+ T cells in patients with non‐small‐cell lung cancer. The key mechanism involves CSC‐derived acetyl‐CoA, which disrupts CD103+ T cell differentiation by sequentially inducing acetylation and ubiquitination of the Blimp‐1 protein. Targeting
Jiaxin Lei, Huiyan Ji, Jing Guo, Mengdi Liu, Danhua Su, Yiran Zheng, Lin Xu, Qinghua Cao, Tao Ren, Jun Gui, Zhenke Wen   +10 more
wiley   +1 more source

腎細胞癌の膵転移の1例 [PDF]

, 1990
A case of asynchronous bilateral renal cell carcinoma with pancreatic metastasis is described. Left nephrectomy and tumorectomy in the right kidney were performed.
Gohji, Kazuo, Kamidono, Sadao, Matsumoto, Osamu   +2 more
core  

ATRX protein is a potential prognostic marker in clear cell renal cell carcinoma

, 2022
Mi Jin Gu, Jin-A Baek, Nuri Jang, Young-Ran Shim   +3 more
openalex   +1 more source

IL4I1⁺ Macrophages and TDO2⁺ Myofibroblasts Drive AhR‐Mediated Immunosuppression and Ferroptosis Resistance in Solid Predominant Lung Adenocarcinoma

Advanced Science, EarlyView.
Solid predominant lung adenocarcinoma exhibits an immune‐excluded, ferroptosis‐resistant niche enriched with IL4I1⁺ TAMs and TDO2⁺ myCAFs. Spatial and multi‐omics analyses reveal AhR‐driven crosstalk that promotes T cell exhaustion and therapy resistance. Blocking AhR with CH‐223191 restores ferroptosis sensitivity, and its combination with ferroptosis
Zhaoxuan Wang, Weijiao Xu, Lei Zhao, Lin Zhong, Wendan Yu, Shengmin Wang, Lu Sun, Tao Guo, Fengzhou Li, Zhuoshi Li, Lei Fang, Shiqing Wang, Guohui Zhang, Guoqing Xue, Wei Guo, Shilei Zhao, Chundong Gu   +16 more
wiley   +1 more source

Ipsilateral synchronous renal pelvic transitional cell carcinoma and renal cell carcinoma: a case report and review of the literature [PDF]

, 1991
腎盂尿管と腎実質の重複腫瘍は稀であり, 現在までに本邦では27例が報告されているにすぎない.肉眼的血尿を主訴として受診し精査の結果, 腎盂移行上皮癌と腎細胞癌の同時同側性重複腫瘍と診断された1例(75歳男)を経験したA case of ipsilateral transitional cell carcinoma of left renal pelvis and left-renal cell carcinoma is presented.
原田, 吉將, 栗山, 学, 武田, 明久, 永井, 司, 河田, 幸道, 篠田, 徳郎, 谷口, 光宏, 高橋, 義人   +7 more
core  

Choosing the optimal therapy for metastatic renal cell carcinoma: Insights from a real‐world comparative study [PDF]

Takuto Hara, Jun Teishima, Yasuyoshi Okamura, Kotaro Suzuki, Yukari Bando, Tomoaki Terakawa, Koji Chiba, Yoji Hyodo, Hideaki Miyake   +8 more
openalex   +1 more source