Results 161 to 170 of about 575,729 (357)

NUSAP1 Recruits DAXX to Suppress HIF‐Driven Triple‐Negative Breast Cancer Progression

Advanced Science, EarlyView.
A double‐negative feedback loop is identified in TNBC where NUSAP1 bridges HIF and DAXX via its microtubule‐associated domain (MAD) to recruit SETDB1, repressing HIF transcriptional activity by depositing the H3K9me3 repressive mark on HIF target genes, while HIF itself suppresses NUSAP1.
Yating Du, Jingjing Wang, Min Wang, Yao Zhang, Miaomiao Zheng, Huiyan Li, Xuemeng Wang, Huanran Sun, Kexin Tang, Changliang Shan, Qiang Zhao, Xiaoqian Meng, Yijie Wang, Jun Zhou, Yan Chen   +14 more
wiley   +1 more source

Integrated single-cell and bulk characterization of branched chain amino acid metabolism-related key gene BCAT1 and association with prognosis and immunogenicity of clear cell renal cell carcinoma [PDF]

Jie Zheng, Yingqing Liu, Jiawei Wang, Jiewu Shi, Linfeng Li, Xuefeng Jiang, Lingsong Tao   +6 more
openalex   +1 more source

Functional, Pharmacogenomic, and Immune Landscapes of Long Non‐Coding RNAs in Cancer

Advanced Science, EarlyView.
A systematic analysis of 33 cancer types reveals widespread associations between lncRNAs and cancer pathways, drug responses, immune features, and immunotherapy outcomes. The study identifies key lncRNAs linked to therapeutic response and adverse events and introduces PILNC, an interactive web portal for exploring the functional, pharmacogenomic, and ...
Runhao Wang, Mei Luo, Yuan Liu, Jingwen Yang, Yamei Chen, Chengxuan Chen, Lifei Ma, Stephanie Ding, James Wengler, Yong Zang, Bora Lim, Wenbo Li, Liuqing Yang, Chunru Lin, Lixia Diao, Leng Han   +15 more
wiley   +1 more source

Nephrectomy for a case of intrarenal dermoid cyst: was it an appropriate decision? [PDF]

, 2011
Dermoid cyst in a kidney is rarely seen. We report a case of intrarenal dermoid cyst which mimics malignant renal tumour and discuss the dilemma in managing this ...
Badrulhisham B,, Christopher CKH,, Goh EH,, Praveen S,, Rozman Z,, Tan GH,, Zulkifli MZ,   +6 more
core  

Bolster material granuloma masquerading as recurrent renal cell carcinoma following partial nephrectomy

, 2016
Abhishek Singh, Shrikant Jai, Sanika Ganpule, Arvind Ganpule   +3 more
openalex   +1 more source

Treatment Outcomes in Patients With Metastatic Renal Cell Carcinoma With Sarcomatoid and/or Rhabdoid Dedifferentiation After Progression on Immune Checkpoint Therapy [PDF]

, 2023
Andrew W. Hahn, Devaki Shilpa Surasi, Paul V. Viscuse, Tharakeswara Bathala, Andrew James Wiele, Matthew T. Campbell, Amado J. Zurita, Amishi Y. Shah, Eric Jonasch, Jianjun Gao, Sangeeta Goswami, Omar Alhalabi, Priya Rao, Kanishka Sircar, Nizar M. Tannir, Pavlos Msaouel   +15 more
openalex   +1 more source

Cancer Stem Cells Shift Metabolite Acetyl‐Coenzyme A to Abrogate the Differentiation of CD103+ T Cells

Advanced Science, EarlyView.
Lei et al. demonstrate that cancer stem cells (CSCs) play a pivotal role in impairing the differentiation of CD103+ T cells in patients with non‐small‐cell lung cancer. The key mechanism involves CSC‐derived acetyl‐CoA, which disrupts CD103+ T cell differentiation by sequentially inducing acetylation and ubiquitination of the Blimp‐1 protein. Targeting
Jiaxin Lei, Huiyan Ji, Jing Guo, Mengdi Liu, Danhua Su, Yiran Zheng, Lin Xu, Qinghua Cao, Tao Ren, Jun Gui, Zhenke Wen   +10 more
wiley   +1 more source

Secondary immune thrombocytopenic purpura with renal cell carcinoma

, 2019
Shigeaki Nakazawa, Masataka Kawamura, Kosuke Nakano, Norichika Ueda, Hidefumi Kishikawa, Hirokazu Kashiwagi, Motohide Uemura, Ryoichi Imamura, Kenji Nishimura, Norio Nonomura   +9 more
openalex   +1 more source

IL4I1⁺ Macrophages and TDO2⁺ Myofibroblasts Drive AhR‐Mediated Immunosuppression and Ferroptosis Resistance in Solid Predominant Lung Adenocarcinoma

Advanced Science, EarlyView.
Solid predominant lung adenocarcinoma exhibits an immune‐excluded, ferroptosis‐resistant niche enriched with IL4I1⁺ TAMs and TDO2⁺ myCAFs. Spatial and multi‐omics analyses reveal AhR‐driven crosstalk that promotes T cell exhaustion and therapy resistance. Blocking AhR with CH‐223191 restores ferroptosis sensitivity, and its combination with ferroptosis
Zhaoxuan Wang, Weijiao Xu, Lei Zhao, Lin Zhong, Wendan Yu, Shengmin Wang, Lu Sun, Tao Guo, Fengzhou Li, Zhuoshi Li, Lei Fang, Shiqing Wang, Guohui Zhang, Guoqing Xue, Wei Guo, Shilei Zhao, Chundong Gu   +16 more
wiley   +1 more source

Therapeutic targeting SPI1 in combination with erastin promotes ferroptosis in ccRCC

Communications Biology
Clear cell renal cell carcinoma is the most common renal cell carcinoma subtype with a poor prognosis. The SPI1/Pu.1, which encodes a member of the E26-transformation-specific family of transcription factors, is highly expressed and associated with poor ...
Wei Xue, Zhengqi Wu, Jixin Li, Peng Jin, Yuze Zhu, Zhiyuan Li, Zhijiao Wang, Zhenhua Li, Xiang Fei   +8 more
doaj   +1 more source