Results 191 to 200 of about 1,140,223 (331)
Advanced Science, EarlyView.This study developed an unsupervised radiomics system integrating CT imaging and multi‐omics data to stratify clear cell renal cell carcinoma into two subtypes with distinct clinical outcomes. Cluster 1 showed lower recurrence risk and active immunity, while Cluster 2 exhibited higher recurrence risk, enriched VHL/KDM5C mutations, immunosuppressive ...
Yusheng Guo +14 more
wiley +1 more source
Advanced Science, EarlyView.SGCD presents a novel approach for tissue spatial domain identification by employing interpolation to estimate inter‐spot gene expression and deconvolution to resolve cell‐type composition in both sampled and interstitial regions. By integrating gene expression, cell type, and spatial coordinates within a graph contrastive learning framework, SGCD ...
Tianjiao Zhang +7 more
wiley +1 more source
A Network‐Driven Framework for Drug Response Precision Prediction of Acute Myeloid Leukemia
Advanced Science, EarlyView.A network‐based precision medicine platform, named NetAML is offered for personalized treatment of AML. It combines network analysis and machine learning to develop 87 models predicting drug sensitivity for clinical drugs. NetAML identifies interpretable gene signatures that drive differential drug responses, enabling the prediction of individual ...
Yinyin Wang +7 more
wiley +1 more source
TRANSLUMBAR RADICAL NEPHRECTOMY FOR RENAL CELL CARCINOMA
, 1989 Iwao Fukui +6 more
openalex +2 more sources
EGFR‐TKIs Induced DPP4 Drives Metabolic Reprogramming of Persister Cells in Lung Cancer
Advanced Science, EarlyView.Drug‐tolerant persister (DTP) cells emerge early during EGFR‐TKI treatment, preceding the development of acquired resistance. Elevated DPP4 in DTP cells drives metabolic reprogramming and antioxidant adaptation, promoting cell survival under drug pressure.
Yuanzhou Zhang +7 more
wiley +1 more source
Synchronous occurrence of hepatocellular carcinoma and renal cell carcinoma: A case report. [PDF]
Int J Surg Case RepSeife H +4 more
europepmc +1 more source
Advanced Science, EarlyView.The present study reveals that PLAUR+ neutrophils are enriched in immunotherapy non‐responders and correlate with poor prognosis. PLAUR+ neutrophils dictate immunotherapy resistance in hepatocellular carcinoma by forming an immunosuppressive tumor microenvironment characterized by CD8+ T cell exclusion and macrophage‐dependent immune suppression.
Shaoqing Liu +11 more
wiley +1 more source
CLINICAL EVALUATION OF 6 ARTERIOVENOUS FISTULAE SECONDARY TO RENAL CELL CARCINOMA
, 1982 Tetsuro Onishi +8 more
openalex +2 more sources