Results 111 to 120 of about 1,433,142 (290)

The role of nitric oxide in nephroprotection during surgical correction of congenital heart disease in children (literature review)

Вестник анестезиологии и реаниматологии
Introduction. The need to develop effective methods of renal protection during cardiac surgical interventions is dictated by the progressive increase of acute kidney injury (CS-AKI) in children, which is associated with immaturity of renal function and ...
P. V. Zinchuk, A. A. Ivkin, E. V. Grigoriev, D. G. Balakhnin   +3 more
doaj   +1 more source

STUDIES ON RENAL CIRCULATION THE RENAL HEMODYNAMICS IN HYPOXIA

Nihon Naika Gakkai Zasshi, 1968
低酸素時の腎循環調節機構を解明するため, pentobarbital sodiumで麻酔した雑種成熟イヌ41頭を用い,低酸素負荷(5%O2•95%N2, 5分間)時の腎旗行動態の変動を研究した.腎神経保存イヌでは低酸素負荷により体血圧の上昇, RBFの減少およびRVRの増大を認めたが,腎神経切断イヌではRVR増大が遅れかつ軽度であつた.自律神経節遮断イヌでは腎血行動態に有意の変化を生じなかつた.一方,体外循環により定圧で左腎を潅流した場合は,低酸素負荷により体血圧上昇, RBF減少, RVRの軽度増大を示した.
openaire   +3 more sources

EXPERIMENTAL STUDIES ON LIGATION OF LEFT RENAL VEIN IN RAT: PART1. EFFECTS OF RENAL FUNCTION AND DEVELOPMENT OF COLLATERAL CIRCULATION [PDF]

, 1977
The renal vein on the left side was ligated and nephrectomy on the right side was performed 7 days later or simultaneously using the male Wistar rats. After another seven days, the remaining kidney function and the state of collateral circulation were ...
川村, 寿一, 大上, 和行, 久世, 益治, 細川, 進一, 吉田, 修, 伊東, 三喜雄   +5 more
core  

THSD7A Exacerbates Atherosclerosis via Activation of Signaling Axis αvβ3/CEBPD/IL1A

Advanced Science, EarlyView.
THSD7A exerts pro‐inflammatory effects and exacerbates atherosclerosis. Mechanistically, THSD7A regulates endothelial cell inflammation and atherosclerosis by activating the αvβ3/CEBPD/IL1A signaling axis. THSD7A is not only a genetic marker but also a potential therapeutic target for coronary artery disease (CAD).
Jiankun Liu, Hongfei Liu, Yiqi Wan, Andong Wu, Jiayu Qiu, Xueting Gong, Ya Zhao, Yuanyuan Li, Bingbing Zhou, Yangyi Zheng, Fang Wu, Yuanzheng Zhu, Weixin Lv, Xueer Li, Qiang Yuan, Xiao‐Li Tian   +15 more
wiley   +1 more source

Diagnostic and prognostic value of Doppler ultrasound study in hepatorenal syndrome. A report of a case

Acta Médica del Centro, 2016
Hepatorenal syndrome is a condition that occurs in patients with chronic liver disease characterized by portal hypertension and it is distinguished by the deterioration of renal function and marked abnormalities in blood circulation, with activation of ...
Raysa Garay Padrón, Milagros Hernández Fernández, Arai Peña Bernal   +2 more
doaj  

Who speaks for whom? Can nurses be patient advocates in renal settings? [PDF]

, 2014
Nursing texts laud the role of nurses as advocates for patients. With increased acknowledgement of patient-centred care, is it appropriate or desired for nurses to presume this as their role?
Wellard, Sally
core  

OAF Blocks SIAH1‐Mediated Degradation of SCPX, a Therapeutic Strategy for MASLD

Advanced Science, EarlyView.
This study shows OAF directly binds to SCPX and inhibits its interaction with the E3 ligase SIAH1, thereby protecting SCPX from ubiquitin‐dependent degradation and stabilizing its levels. This OAF‐SCPX axis represents a novel pathway in lipid homeostasis, highlighting OAF as a promising therapeutic candidate for MASLD.
Zongxi Li, Jingyue Song, Kaili Ma, Shunan Tang, Shuqian Wang, Wenya Ji, Chen Lu, Ting Zhang, Huaping Zheng, Xiaowei Zheng, Shanshan Lai, Cheng Deng   +11 more
wiley   +1 more source

Natural Product Toosendanin Suppresses the Malignant Development of Skin Melanoma by Targeting BNC2 for Degradation

Advanced Science, EarlyView.
BNC2 exhibits context‐dependent opposing functions across multiple cancer types. This study reveals BNC2 as an oncogenic driver of melanoma proliferation and metastasis through transcriptional activation of PIK3CA. The natural compound TSN simultaneously degrades BNC2 and its oncogenic partner SMAD3 via CRBN‐dependent ubiquitination.
Hui Dai, Xin Mei Zhang, Jing Cheng Zhang, Xu Ting Deng, Qiao Liu, Mustafa Hussein Ali, Fang Zhou Yin, Wu Yin   +7 more
wiley   +1 more source

14‐3‐3γ Protects Against Postoperative Cognitive Dysfunction by Regulating Tau Thr205 Phosphorylation and Synaptic Integrity

Advanced Science, EarlyView.
Integrative multi‐cohort analyses identify 14‐3‐3γ as a biomarker and regulator of cognitive vulnerability. Experimental studies show that 14‐3‐3γ loss is associated with Tau Thr205 phosphorylation, synaptic dysfunction, and cognitive impairment, while genetic overexpression or pharmacological stabilization of 14‐3‐3γ confers protective effects in ...
Shouqiang Zhu, Xue Han, Heng Zhang, Chang Ye, Tianjiao Xia, Xiaoping Gu   +5 more
wiley   +1 more source

Reversing Macrophage Immunometabolic Dysfunction in Prolonged Infections Via a Glutaminolysis‐Fueled Restoration‐Based Hierarchically Selective Therapeutic System

Advanced Science, EarlyView.
A hierarchically selective immunotherapeutic nanoplatform, mGls@HEV‐MTP, selectively restores macrophage immunocompetence through GLS1‐mediated restoration of glutaminolysis‐fueled anaplerosis. Concurrently, it renders Staphylococcus aureus (S. aureus) more readily recognizable to the metabolically reprogrammed macrophages, thereby facilitating ...
Weinan Yang, Zihao An, Honglu Cai, Congsun Li, Jiaxuan Zou, Wushi Cui, Wentao Chen, Tao Zhang, Shicheng Wang, Zizhan Su, Jian Xiao, Tao Sun, Bin Hu, Min Cheng, Zhongru Gou, Jianbin Xu, An Liu, Haobo Wu   +17 more
wiley   +1 more source