Results 111 to 120 of about 1,354,926 (279)
Advanced Science, EarlyView.Safe and precise bioorthogonal therapy of tumors was achieved by an ultrasound‐responsive heterostructured nanoreactor with on‐demand catalytic activity. Under piezoelectric catalysis, the system undergoes reversible Pd2+/Pd0 redox cycling, concurrently enabling spatiotemporally controlled prodrug activation and self‐terminating catalytic dose ...
Daqing Xia +9 more
wiley +1 more source
Acta Médica del Centro, 2016 Hepatorenal syndrome is a condition that occurs in patients with chronic liver disease characterized by portal hypertension and it is distinguished by the deterioration of renal function and marked abnormalities in blood circulation, with activation of ...
Raysa Garay Padrón +2 more
doaj
Вестник анестезиологии и реаниматологииIntroduction. The need to develop effective methods of renal protection during cardiac surgical interventions is dictated by the progressive increase of acute kidney injury (CS-AKI) in children, which is associated with immaturity of renal function and ...
P. V. Zinchuk +3 more
doaj +1 more source
STUDIES ON RENAL CIRCULATION THE RENAL HEMODYNAMICS IN HYPOXIA
Nihon Naika Gakkai Zasshi, 1968 低酸素時の腎循環調節機構を解明するため, pentobarbital sodiumで麻酔した雑種成熟イヌ41頭を用い,低酸素負荷(5%O2•95%N2, 5分間)時の腎旗行動態の変動を研究した.腎神経保存イヌでは低酸素負荷により体血圧の上昇, RBFの減少およびRVRの増大を認めたが,腎神経切断イヌではRVR増大が遅れかつ軽度であつた.自律神経節遮断イヌでは腎血行動態に有意の変化を生じなかつた.一方,体外循環により定圧で左腎を潅流した場合は,低酸素負荷により体血圧上昇, RBF減少, RVRの軽度増大を示した.
openaire +3 more sources
Advanced Science, EarlyView.ABSTRACT Background Therapeutic resistance limits durable survival in advanced/metastatic renal cell carcinoma (RCC) treated with first‐line tyrosine kinase inhibitor (TKI) plus immune checkpoint inhibitor (ICI). We sought to define key resistance drivers and actionable targets.
Jinchen Luo +16 more
wiley +1 more source
Advanced Science, EarlyView.A NIR‐II light‐activatable thermoelectric nanoreactor converts surface‐bound Cu2+ into bioactive Cu+ via directed electron flow. This spatiotemporally controlled reduction triggers potent cuproptosis and immunogenic cell death, eradicating primary tumors and, together with aPD‐1 therapy, suppressing metastases while establishing durable immune memory ...
Boyu Yuan +10 more
wiley +1 more source
Advanced Science, EarlyView.A highly sensitive SERS‐based platform measures PD‐L1 expression on EpCAM+ circulating EVs from cancer patients undergoing immunotherapy. Monitoring dynamic changes after treatment reveals that reduced EpCAM+ EV PD‐L1 levels associate with improved long‐term clinical outcomes, establishing a non‐invasive approach for tracking immune checkpoint ...
Byeonggeol Mun +15 more
wiley +1 more source
Who speaks for whom? Can nurses be patient advocates in renal settings? [PDF]
, 2014 Nursing texts laud the role of nurses as advocates for patients. With increased acknowledgement of patient-centred care, is it appropriate or desired for nurses to presume this as their role?
Wellard, Sally
core
Advanced Science, EarlyView.In sepsis‐induced liver injury, marked neutrophil infiltration correlates with disease severity. Neutrophil SLC11A1 drives intracellular Fe2+ and ROS via the Fenton reaction, promoting NETs formation. Hepatocyte‐derived CXCL10 recruits neutrophils and activates the JAK/STAT1/SLC11A1 axis, enhancing NETs‐mediated inflammation.
Haiping Lin +8 more
wiley +1 more source
Advanced Science, EarlyView.We constructed a brain‐targeted AFn‐DPZ nanodrug delivery system and identified EphB1 as its receptor on the blood‐brain barrier (BBB). This system facilitates drug transport across the BBB and thereby ameliorates cognitive impairment in Alzheimer's disease.
Shilin Wen +5 more
wiley +1 more source