Results 181 to 190 of about 2,405,382 (374)

REACTIVITY OF RENAL AND SYSTEMIC CIRCULATIONS TO VASOCONSTRICTOR AGENTS IN NORMOTENSIVE AND HYPERTENSIVE SUBJECTS* [PDF]

open access: bronze, 1962
Ervin A. Gombos   +5 more
openalex   +1 more source

Endogenous Ceramide 24:1 Constrains Th17‐Driven Neutrophilic Inflammation by Antagonizing EP2 Signaling

open access: yesAdvanced Science, EarlyView.
Cer24:1 levels are reduced in neutrophilic asthma and inversely correlate with disease severity and airway neutrophilia. Restoring Cer24:1 suppresses pathogenic Th17 differentiation by engaging EP2 on CD4+ T cells, thereby dampening the JAK2–STAT3–RORγt axis and reducing IL‐17 production.
Huan Liu   +11 more
wiley   +1 more source

ПАТОМОРФОЛОГИЧЕСКАЯ ХАРАКТЕРИСТИКА ВНУТРЕННИХ ОРГАНОВ КРЫС ПРИ ОСТРОЙ И ХРОНИЧЕСКОЙ ИНТОКСИКАЦИИ ИВЕРТИНОМ

open access: yesВетеринарная патология, 2009
The character and degree of morphological changes of internal organs of laboratory rats at acute and chronic intoxication of Ivertin was investigated. Morphological studies showed that for chronic intoxication was typical the mixed parenchymatous-fatty ...

doaj  

A Renal Clearable Probe for In Vivo Monoamine Oxidase (MAO) Detection

open access: yesAdvanced Science, EarlyView.
A renal‐clearable Cy7‐based fluorogenic probe enables rapid and non‐invasive detection of monoamine oxidase (MAO) activity in vivo. Upon MAO‐mediated activation, the fluorescent product is efficiently excreted in urine, allowing direct quantification of enzyme overexpression.
Marcia Domínguez   +13 more
wiley   +1 more source

Profiling Localized Immunomodulation and Drug Biodistribution within a Subcutaneous Vascularized Niche for Cell Transplantation

open access: yesAdvanced Science, EarlyView.
We studied how five common immunosuppressants behave when delivered directly to a transplant site instead of systemically. Using a vascularized implant for islet transplantation, we show that local delivery protects grafts, limits drug spread to the rest of the body, and produces distinct immune signatures.
Jocelyn Nikita Campa‐Carranza   +19 more
wiley   +1 more source

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