Results 61 to 70 of about 1,354,926 (279)

Impaired microvascular circulation in distant organs following renal ischemia.

PLoS ONE, 2023
Mortality in acute kidney injury (AKI) patients remains very high, although very important advances in understanding the pathophysiology and in diagnosis and supportive care have been made. Most commonly, adverse outcomes are related to extra-renal organ
Jesus H Dominguez, Danhui Xie, K J Kelly
doaj   +1 more source

Microvascular damage is associated with carotid wall structural changes in Systemic Sclerosis: a capillaroscopy and ultrasound‐based observational study

Arthritis Care &Research, Accepted Article.
Introduction Systemic sclerosis (SSc) is characterized by cardiovascular risk excess not fully explained by traditional factors. Whether the severity of microvascular damage correlates with structural subclinical atherosclerosis remains unclear. We investigated the relationship between nailfold videocapillaroscopy (NVC) abnormalities and carotid ...
Eugenio Capparelli, Luca Clerici, Francesco Lapia, Giusy C. Moltisanti, Eleonora Zaccara, Greta Pellegrino, Daniela Bompane, Francesca Capelli, Letizia Ferrami, Laura Castelnovo, Antonio Tamburello, Maria Sole Chimenti, Paola Faggioli, Antonino Mazzone   +13 more
wiley   +1 more source

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

RENAL PORTAL CIRCULATION IN CHICKENS

The Japanese Journal of Veterinary Science, 1973
腎門脈弁におよぼす薬物の影響をinvivoで研究した報告は皆無であるばかりでなく,血流を直接的方法で測定した報告もない.鶏において,とくに尾腸間膜静脈(CMV)の血流量とその方向を決定することは,これまでの血流循環系分野の最大の関心事の一つであった.従って,著者らは,実験材料として白色レグホーンの雄を選び,麻酔下で電磁血流計を用いて,CMVの血流の方向を調べ,CMVおよび後大静脈(IVC)の血流量を測定した.また同時に心拍数および頚動脈血圧も測定した.10μg/kgのnorepinephrinc(NE)ならびに0.1mg/kgのacctylcholine(Ach)を翼下静脈に注射して,血流量およびCMVの血流方向の変化から,腎門脈弁に対する薬物の作用を研究することが,本実験の目的である ...
SHIMADA, Kiyoshi, STURKIE, Paul D
openaire   +3 more sources

Single-dose pharmacokinetics of recombinant human erythropoietin in patients with various degrees of renal failure [PDF]

, 1989
The pharmacokinetic profile of recombinant human erythropoietin (rHuEpo) was studied after a single intravenous dose of 150 U/kg in ten patients with various degrees of renal function: group I, creatinine clearance greater than 80 ml/min, n = 2; group II,
K. Jandeleit, Eckardt, K. U., A. Kurtz, B. Ehmer, A. Schreiber, Sieberth, H. G., Kindler, J., Jandeleit, K., Schreiber, A., Ehmer, B., Kurtz, Armin, Sieberth, H.-G., K.-U. Eckardt, Kurtz, A., H.-G. Sieberth, P. Scigalla, Scigalla, P., Eckardt, Kai-Uwe, J. Kindler   +18 more
core   +1 more source

Bio‐Inspired Biopolymeric Implantable Platform for Localized and Sustained Drug Delivery in Solid Tumor Treatment

Advanced Functional Materials, EarlyView.
A bio‐inspired biopolymeric implantable drug delivery platform enables localized and sustained release of 7‐ethyl‐10‐hydroxycamptothecin (SN‐38) in solid tumor treatment. The three‐dimensional (3D) structured crosslinked‐chitosan implants are fabricated via 3D‐printed molds and provide drug release over 3 months, significantly inhibiting tumor growth ...
Mercedes Lozano‐Garcia, Constantine Vogiatzis, Alejandra Planells‐Devesa, Emre Dikici, Caroline Vieira Maluf, Vasudev Vivekanand Nayak, Paulo G. Coelho, Lukasz Witek, Alicia Bilbao, Daniel Bilbao, Prasoon Mohan, Sapna Deo, Sylvia Daunert   +12 more
wiley   +1 more source

Magnitude and variability of blood pressure and renal vascular conductance responses to postural changes, exercise, and cold in black adults: A pilot study

Physiological Reports
We developed a noninvasive approach to measure vascular responses to sympathetic stimuli. We hypothesized that standing, handgrip exercise, or cold exposure would raise blood pressure (BP) and lower renal vascular conductance (RVC).
Mohamed H. Ibrahim, Alison J. McLure, Mary J. Jackson, Brittany Harrison, Sarah Brockley, Elizabeth C. Jones, A. Parker Ruhl, Hans C. Ackerman   +7 more
doaj   +1 more source

Metabolism and secretion of retinol transport complex in acute renal failure

Journal of Lipid Research, 1991
Tissue uptake and distribution of retinol from circulatory vitamin A transport complex was studied in order to determine the origin of the increased serum retinol in rats with short-term acute renal failure.
TH Gerlach, MH Zile
doaj   +1 more source

Multifunctional Neutrophil Nanovesicles Induce Remodeling of Tumor Immune Microenvironment and Synergistic Multimodal Tumor Therapy

Advanced Functional Materials, EarlyView.
Schematic illustration of the engineered RN@FDT for multimodal tumor therapy. a) Fabrication of FD&DOX/TFA‐loaded RGD‐NNV (RN@FDT) and the light‐triggered disassemble of RN@FDT. b) After internalized by tumor cells, RN@FDT are disintegrated under NIR‐II laser irradiation to boost PTT and induce cell apoptosis.
Jiahui Zhang, Cheng Ji, Xin‐Jian Fang, Yu Qian, Jiayuan Shi, Wenhui Liu, Baiyuan Fan, Yuan Zhong, Jiayi Wang, Dan Yu, Maoye Wang, Min Fu, Xiaoxin Zhang, Runbi Ji, Hélder A. Santos, Hongbo Zhang, Xu Zhang   +16 more
wiley   +1 more source

Hepatorenal syndrome

Annals of Hepatology, 2003
Hepatorenal syndrome is complication of advanced cirrhosis characterized by renal failure, changes in systemic blood pressure, and increased activity of endogenous vasoactive systems.
Andrés Cárdenas, M.D., Vicente Arroyo, M.D.   +1 more
doaj   +1 more source