Results 91 to 100 of about 1,047,595 (303)

Real‐World Safety of Concomitant Colchicine and Statin Therapy

Arthritis Care &Research, EarlyView.
Objective This study aimed to evaluate the risk of clinically meaningful muscle‐ and liver‐related outcomes associated with concomitant colchicine–statin therapy in a real‐world setting, and to determine whether concomitant therapy increases the incidence of toxicity compared with either agent alone.
Roni Meidan, Ranel Loutati, Dan Caspi, Ori Elkayam, Ran Abuhasira, Tali Eviatar   +5 more
wiley   +1 more source

Impact of inferior vena cava obstruction during orthotopic liver transplantation without venovenous bypass grafting on early postoperative renal function (pilot analysis)

Трансплантология (Москва), 2018
Ligation of the inferior vena cava (IVC) during classical orthotopic liver transplantation (OLT) may be followed by pronounced hemodynamic changes and may provoke renal dysfunction.
Ye. O. Santotsky, A. F. Minov, D. I. Yurlevich, L. V. Kirkovsky, S. V. Korotkov, D. P. Kharkov, L. S. Bolonkin, Yu. V. Slobodin, Ye. L. Avdei, A. M. Fedoruk, A. M. Dzyadzko, A. Ye. Shcherba, O. O. Rummo, I. L. Kulinkovich, P. V. Kozich   +14 more
doaj   +1 more source

Passing through the renal clearance barrier: toward ultrasmall sizes with stable ligands for potential clinical applications

, 2014
Xiao-Dong Zhang,1 Jiang Yang,2 Sha-Sha Song,1 Wei Long,1 Jie Chen,1 Xiu Shen,1 Hao Wang,1 Yuan-Ming Sun,1 Pei-Xun Liu,1 Saijun Fan11Tianjin Key Laboratory of Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences
Yang J, Long W, Zhang XD, Chen J, Song SS, Wang H, Shen X, Sun YM, Liu PX, Fan S   +9 more
core  

Human renal clearance of xenobiotics

Dataset contains human renal clearance values of exogenous substances. The final set contains over 1,700 experimental observations from 761 scientific articles and covers over 500 unique substances studied.
Polak, Sebastian
core   +1 more source

Survival Outcomes in Older Adults With Axial Spondyloarthritis and Concomitant Cancer

Arthritis Care &Research, EarlyView.
Objective The objective of this study was to determine survival outcomes in older adults with axial spondyloarthritis (axSpA) and concomitant cancer. Methods We conducted a population‐based study using Medicare claims data linked to Surveillance, Epidemiology, and End Results data to determine overall survival (OS) and cancer‐specific survival (CSS) in
Savannah Bowman, Mei Li, Xiudong Lei, Hui Zhao, Juan I. Ruiz, Sharon H. Giordano, Alexis R. Ogdie, Maria E. Suarez‐Almazor   +7 more
wiley   +1 more source

Renal safety of a tenofovir-containing first line regimen: experience from an antiretroviral cohort in rural lesotho. [PDF]

, 2011
Current guidelines contraindicate TDF use when creatinine clearance (CrCl) falls below 50 ml/min. We report prevalence of abnormal renal function at baseline and factors associated with abnormal renal function from a community cohort in ...
Bygrave, Helen, Triviño, Laura, Hilderbrand, Katherine, Lipontso Makakole, Katherine Hilderbrand, Vlahakis, Nathalie, Ford, Nathan, Helen Bygrave, Jouquet, Guillaume, Nathalie Vlahakis, Guillaume Jouquet, Katharina Kranzer, Goemaere, Eric, Nathan Ford, Makakole, Lipontso, Kranzer, Katharina, Eric Goemaere, Laura Triviño   +17 more
core   +2 more sources

Development of Patient‐Reported Outcome Measures for Early Systemic Sclerosis Across Disease Subtypes

Arthritis Care &Research, Accepted Article.
Objective Existing patient‐reported outcome (PRO) measures for systemic sclerosis (SSc) have important limitations, including inadequate coverage of early disease and limited inclusion of diffuse cutaneous (dcSSc) and limited cutaneous (lcSSc) subtypes.
George J. Greene, Chelsea Rose Perschon, Emilie Jaeger, Alain Lescoat, David Cella, Dinesh Khanna   +5 more
wiley   +1 more source

Acute vasodilator therapy increases renal clearance of digoxin in patients with congestive heart failure.

, 1981
We studied the effect of vasodilator therapy on renal digoxin clearance in patients with chronic congestive heart failure. Intravenous administration of nitroprusside or hydralazine to eight patients with severe heart failure produced the expected ...
C J Carlson, M H Humphreys, J J Cogan, N L Benowitz, E Rapaport   +4 more
core   +1 more source

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

Dysregulation of the mRNA Expression of Human Renal Drug Transporters by Proinflammatory Cytokines in Primary Human Proximal Tubular Epithelial Cells

Pharmaceutics
Proinflammatory cytokines, which are elevated during inflammation or infections, can affect drug pharmacokinetics (PK) due to the altered expression or activity of drug transporters and/or metabolizing enzymes.
Yik Pui Tsang, Tianran Hao, Qingcheng Mao, Edward J. Kelly, Jashvant D. Unadkat   +4 more
doaj   +1 more source