Results 131 to 140 of about 1,047,595 (303)

ROS Self‐Supply Nanoplatform Based on Fenton Catalyst for Chemodynamic and Immunotherapy: Reprogramming Cold Tumor Into Hot Tumor in Cancer Treatment

Advanced Science, EarlyView.
A multifunctional HA‐conjugated nanoplatform (HA‐PGMC) integrates CuO2, glucose oxidase, and mil‐100 to enable cascade catalytic ROS generation in tumor microenvironments. This self‐supplying ROS strategy induces immunogenic cell death, reprograms “cold” tumors into “hot” ones, and synergizes with PD‐L1 blockade, achieving potent chemodynamic ...
Man Lung Lee, Jack Chun Hin Chen, Wai Wing Cheng, Kwan Yee Lau, Hiu Yee Kwan, Ngar‐Yun Ellen Poon, Hung‐Wing Li   +6 more
wiley   +1 more source

An Activity‐Reinforced P‐Modified Single‐Atom Cu Nanozyme Potentiates IDO Blockade‐Induced Tumor Radiotherapy

Advanced Science, EarlyView.
A phosphorus‐modified single‐atom copper nanozyme delivering the IDO1 inhibitor 1‐methyl‐tryptophan enhances breast cancer radioimmunotherapy by simultaneously relieving hypoxia and inducing immunogenic cell death through dual enzyme activities while blocking tryptophan metabolism to suppress regulatory T cell function.
Wei Zhao, Songliu Hu, Zhanggui Wang, Liqun Wang, Liming Zhang, Qi Li, Hua Tang, Yang Zhong, Zhongxian Zhang, Kelong Fan, Shipeng Ning, Xiyun Yan   +11 more
wiley   +1 more source

The Renal Clearance of Digoxin is Dependent upon the Serum Digoxin Concentration1

, 1980
Gibson, Thomas P. and Antonio P.
Thomas P Gibson, Antonio P Quintanilla
core  

Ultrasound‐Activatable Piezoelectric Hydrogel Reprograms Mitochondrial Epigenetics for Osteoarthritis Therapy via the mTOR/GATD3A Axis

Advanced Science, EarlyView.
An ultrasound‐activatable piezoelectric hydrogel reprograms chondrocyte mitochondrial epigenetics via the mTOR/GATD3A axis, clearing damaged mitochondria and alleviating osteoarthritis progression in both mouse models and human cartilage explants. ABSTRACT The avascular nature of cartilage hinders drug delivery for osteoarthritis (OA) therapy.
Hui Zheng, Pengfei Yan, Peng Liu, Chang Yan, Mengqi Zhao, Zuyong Wang, Chao Ma, Rongkai Zhang, Xi Cui, Swee Hin Teoh   +9 more
wiley   +1 more source

Renal clearance rate, estimated renal reabsorption ratio, and kidney proteome of Holstein dairy cows with divergent milk urea concentrations

Frontiers in Molecular Biosciences
Recent mRNA expression studies have proposed various renal proteins to be involved in the excretion of electrolytes, amino acids, and charged compounds to reduce urea, uric acid, and the creatinine clearance rates of dairy cows with high milk urea (HMU ...
Franziska Koch, Dirk Albrecht, Solvig Görs, Carolin B. M. Müller-Kiedrowski, Carolin B. M. Müller-Kiedrowski, Klaus Wimmers, Björn Kuhla   +6 more
doaj   +1 more source

Lactam dosage regimens in septic patients with augmented renal clearance

, 2018
Augmented renal clearance is commonly observed in septic patients and may result in insufficient -lactam serum concentrations. The aims of this study were to evaluate potential correlations between drug concentrations or total body clearance of -lactam ...
Creteur, Jacques, Hites, Maya, Jacobs, Frédérique, Vincent, Jean Louis, Jacobs, Alexandra, Taccone, Fabio, Cotton, Frédéric, Roberts, Jason J.A., Wolff, Fleur   +8 more
core   +1 more source

Ultra‐Radiostable Covalent Conformationally Interlocked Networks Enabling a Universal Radiometal‐Labeling Platform for Cancer Radioembolization

Advanced Science, EarlyView.
Conjugated poly(imide dioxime)‐based microspheres establish a radiometal coordination‐driven conformational interlocked network with ultra‐high radiostability. This platform enables low‐temperature, multi‐radionuclide labeling for SPECT/PET/MRI imaging and radionuclide therapy. Mechanistic insights from EXAFS and DFT reveal enhanced stability, while in
Xiao Xu, Zhenwen Zhao, Yangjie Wang, Zhigang Liu, Zhijie Liu, Xiaoling Li, Zhichen Mao, Lu Xu, Gan Lin, Gang Liu, Hongjuan Ma   +10 more
wiley   +1 more source

OUTCOME OF PERCUTANEOUS NEPHROLITHOTOMY IN RENAL ANOMALIES: SINGLE CENTER EXPERIENCE

Pakistan Journal of Medicine and Dentistry, 2019
Background: PCNL is standard surgical treatment for renal stone > 2.0 cm and stone resistant to Extracorporeal Shock Wave Lithotripsy. This study was conducted to evaluate the outcome of percutaneous nephrolithotomy in renal anomalies. Methods:
Shariq Anis Khan, Salman El Khalid, Suneel Kumar, Fouzia Naeem Effendi, Adnan Siddiq Awan, Muhammad Hammad Ali Mithani   +5 more
doaj  

A Rare De Novo Missense Mutation in IFT122 Confers a Genetic Susceptibility Factor of Idiopathic Pediatric Uveitis Via Trio‐based Whole‐Exome Sequencing

Advanced Science, EarlyView.
A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou, Jiaxing Huang, Yilin Wang, Xingran Li, Xianyang Liu, Lingyu Dai, Hongshun Li, Qingfeng Wang, Jiangyi Liu, Guannan Su, Wanyun Zhang, Yang Deng, Qingfeng Cao, Yujie Lai, Xiang Luo, Changwei Huang, Ling Chen, Shengping Hou, Peizeng Yang   +18 more
wiley   +1 more source

Steviol effect, a glycoside of Stevia rebaudiana, on glucose clearances in rats

Brazilian Journal of Biology
Stevia rebaudiana, a South American plant normally used as a natural herbal sweetener, has been suggested as exerting beneficial effects on human health, including as an antihypertensive and antihyperglycemic.
MS. Melis, ST. Rocha, A. Augusto
doaj   +1 more source