Results 61 to 70 of about 1,047,595 (303)
FEBS Letters, EarlyView.Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise +5 more
wiley +1 more source
Role of ABCB1 and ABCB4 in renal and biliary excretion of perfluorooctanoic acid in mice
Environmental Health and Preventive MedicineBackground: Perfluorooctanoic acid (PFOA) is one of the major per- and polyfluoroalkyl substances. The role of ATP-binding cassette (ABC) transporters in PFOA toxicokinetics is unknown.
Kazuyoshi Furukawa +6 more
doaj +1 more source
Folia Histochemica et Cytobiologica, 2010 The aim of the study was the explain the mechanism related to therapeutic effects of Uremic Clearance Granules (Niaoduqing Keli in Chinese) on adenine-induced Chronic Renal Failure in rats.
Cheng-Bin Chen +5 more
doaj +1 more source
Frontiers in Psychiatry, 2021 Objective: To explore the effects of anxiety and depression on the self-management ability and endogenous creatinine clearance rate of renal transplant patients.Method: Eighty-eight renal transplant recipients who were followed up in the outpatient ...
ShiMin Hu +7 more
doaj +1 more source
Physicochemical Determinants of Human Renal Clearance
, 2016 Kidney plays an important role in the elimination of drugs, especially with low or negligible hepatic clearance. An analysis of the interrelation of physicochemical properties and the human renal clearance for a data set of 391 drugs or compounds tested ...
Manthena V. S. Varma (2319313) +6 more
core +1 more source
Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy
FEBS Letters, EarlyView.The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley +1 more source
FEBS Letters, EarlyView.Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana +3 more
wiley +1 more source
Renal Clearance of Glucosamine in the Rat.
Experimental Biology and Medicine, 1963 Discussion and summaryThat the clearance of exogenous glucosamine in the rat occurs at the same rate as that of inulin suggests that glucosamine might be a substance which after glomerular filtration does not undergo subsequent tubular reabsorption or secretion.
J D, CLAYTON, M K, CARTER
openaire +2 more sources
Assessment of GFR by four methods in adults in Ashanti, Ghana : the need for an eGFR equation for lean African populations [PDF]
, 2010 Background. Equations for estimating glomerular filtration rate (GFR) have not been validated in Sub-Saharan African populations, and data on GFR are few. Methods.
Frank B. Micah +24 more
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source