Results 21 to 30 of about 15,316 (159)

A role for epithelium‐derived 6‐nitrodopamine on human ureter contractility

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose To investigate the basal release of 6‐nitrodopamine (6‐ND) from human isolated ureter and the role of this novel catecholamine in the ureter contractility. Experimental Approach Ureters from 67 brain‐dead organ donors (40 males and 27 females) were used during kidney transplantation procedures.
Wilmar Azal Neto, Denis Lima Oliveira, José Britto‐Júnior, Alex Henrique Miller, Flaviano Lorenzon, Felipe Fernandes Jacintho, Valéria Barbosa de Souza, Fernanda Viviane Mariano, André Almeida Schenka, Fabiola Zakia Mónica, Adriano Fregonesi, Edson Antunes, Gilberto De Nucci   +12 more
wiley   +1 more source

Novel therapeutic targets for chronic visceral pain in gastrointestinal disorders

British Journal of Pharmacology, EarlyView.
Chronic visceral pain imposes a major clinical challenge in gastroenterology and beyond, profoundly impacting patients' quality of life. However, limited understanding of its complex, multifaceted pathophysiology, encompassing both peripheral and central mechanisms, continues to impede the development of effective management strategies.
Fleur Veldman, Christopher J. Black, Andrea Shin, Daniel Keszthelyi   +3 more
wiley   +1 more source

Rationale and design of a parallel randomised trial of a plant‐based intensive lifestyle intervention for diabetes remission: The REmission of diabetes using a PlAnt‐based weight loss InteRvention (REPAIR) trial

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims As type 2 diabetes (T2D) continues to rise globally and remains a major driver of cardiovascular disease, its remission has emerged as a therapeutic target. Current evidence supports bariatric surgery and low‐calorie diets with meal replacements.
Brighid McKay, Dayana El Chaar, Melanie Paquette, Michael Vallis, Diana Sherifali, Paul Oh, Susan Marzolini, Kaberi Dasgupta, Gillian Booth, Mike Lean, Hertzel C. Gerstein, Jordi Salas‐Salvadó, Jacqueline L. Beaudry, Christopher P. F. Marinangeli, Russell J. de Souza, Lawrence A. Leiter, Cyril W. C. Kendall, David J. A. Jenkins, John L. Sievenpiper, Laura Chiavaroli   +19 more
wiley   +1 more source

Renal tubular acidosis in a mule mare

Equine Veterinary Education, EarlyView.
Summary Renal tubular acidosis (RTA) in horses is differentiated into type I (distal) and type II (proximal) forms. We report the diagnostic evaluation and treatment of type I RTA in a 13‐year‐old mule mare that was referred because of lethargy and inappetence of several weeks' duration as well as lack of manure, anorexia and mild colic for 3 days.
L. Kummer, K. Lohmann, C. Arnold
wiley   +1 more source

Possible association of short‐term complications and antimicrobial use in standing equine cheek tooth extractions 2018–2022

Equine Veterinary Journal, EarlyView.
Abstract Background Despite growing concerns about antimicrobial resistance, prophylactic antimicrobials continue to be routinely administered in many procedures, including dental extractions. Further evidence‐based research is needed on whether their use influences post‐operative complication rates.
Marlies Schnierer, Omid Nekouei, Lisa Christina Huber, Matthias Jehle, Nora Biermann   +4 more
wiley   +1 more source

Outbreak of poisoning by sodium hydrogen methylarsonate (MSMA)—an arsenic‐based herbicide—in horses in Brazil

Equine Veterinary Journal, EarlyView.
Abstract Background Arsenic poisoning in horses is rarely reported in the literature. However, arsenic compounds can be present in rodenticides, pesticides, and herbicides, representing a potential source of accidental exposure for horses. Objective To describe the epidemiological, clinical, and laboratory findings from a herd of 31 horses exposed to ...
Gabriella Faria Pereira, Maria Clara Hornich Blimbliem, Anna Laura Previato Rosa Machado, Junara Bianca Rosa Abdala, Geison Morel Nogueira, Hugo Shisei Toma, Tatiane Furtado de Carvalho, Diego José Zanzarini Delfiol   +7 more
wiley   +1 more source

The junction between the midgut and hindgut co‐localizes with the rectosigmoid junction

Journal of Anatomy, EarlyView.
At 5 weeks of development, the midgut has formed its primary loop (left). It is well established that the midgut is bounded cranially by the caudal end of the ventral mesentery and the presence of the common bile duct, but its caudal boundary remains to be established.
Hui Gao, Nutmethee Kruepunga, Greet Mommen, Susanne E. Köhler, Jill P. J. M. Hikspoors, Wouter H. Lamers   +5 more
wiley   +1 more source

The Effects of Daridorexant on Patients With Comorbid Insomnia Disorder and Untreated Mild Obstructive Sleep Apnoea: A Post Hoc Subgroup Analysis of a Phase 3, Randomised Clinical Trial

Journal of Sleep Research, EarlyView.
ABSTRACT Daridorexant, a dual orexin receptor antagonist, is approved for the treatment of insomnia disorder in adults. Approximately 30%–35% of patients with insomnia disorder also have obstructive sleep apnoea (OSA) of any severity. It is unclear whether sleep medications provide safe and effective treatment for insomnia in these patients.
Christopher J. Lettieri, Orestis Briasoulis, Damien Léger, Pierre‐Philippe Luyet, Jean‐Louis Pépin, Stuart F. Quan, Janna Raphelson, Paul Saskin, Atul Malhotra   +8 more
wiley   +1 more source

Increases in skin perfusion and blood oxygen in the non‐exercising human limbs during exercise in the heat: Implications for control of circulation

Experimental Physiology, EarlyView.
Abstract Blood flow in the inactive limb tissues and skin is widely thought to decline during incremental exercise to exhaustion due to augmented sympathoadrenal vasoconstrictor activity, but direct evidence to support this view is lacking. Here, we investigated the inactive‐forearm haemodynamic (Q̇forearm${\dot{Q}}_{\mathrm{forearm}}$) and oxygenation
Steven J. Trangmar, José González‐Alonso   +1 more
wiley   +1 more source

A multi‐omics investigation of sarcopenia and frailty: Integrating genomic, epigenomic and telomere length data

Experimental Physiology, EarlyView.
Abstract Sarcopenia and frailty are complex geriatric syndromes influenced by a combination of genetic and environmental factors. Recent studies suggest that specific genetic variants, DNA methylation patterns and shortened telomeres are associated with age‐related diseases and might contribute to the development of both sarcopenia and frailty. In this
Valentina Ginevičienė, Erinija Pranckevičienė, Alina Urnikytė, Laura Jurkūnaitė, Kristijona Gutauskaitė, Rūta Dadelienė, Justina Kilaitė, Ieva Eglė Jamontaitė, Asta Mastavičiūtė, Ildus I. Ahmetov, Vidmantas Alekna   +10 more
wiley   +1 more source