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American Journal of Kidney Diseases, 2022
Uncontrolled hypertension persists as an important health issue despite the availability of many medications and nondrug therapies that lower blood pressure. Increasingly, nonadherence to medication is found in approximately 2 of every 5 patients with uncontrolled hypertension.
Jimena, Rey-García, Raymond R, Townsend
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Uncontrolled hypertension persists as an important health issue despite the availability of many medications and nondrug therapies that lower blood pressure. Increasingly, nonadherence to medication is found in approximately 2 of every 5 patients with uncontrolled hypertension.
Jimena, Rey-García, Raymond R, Townsend
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European Journal of Internal Medicine, 2015
Renal denervation (RDN) has, within recent years, been suggested as a novel treatment option for patients with resistant hypertension. This review summarizes the current knowledge on this procedure as well as limitations and questions that remain to be answered.The Symplicity HTN-1 (2009) and HTN-2 (2010) studies re-introduced an old treatment approach
Lene Kjær Olsen +3 more
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Renal denervation (RDN) has, within recent years, been suggested as a novel treatment option for patients with resistant hypertension. This review summarizes the current knowledge on this procedure as well as limitations and questions that remain to be answered.The Symplicity HTN-1 (2009) and HTN-2 (2010) studies re-introduced an old treatment approach
Lene Kjær Olsen +3 more
+6 more sources
Hypertension, 2016 Blood pressure response to renal denervation is highly variable, and the proportion of responders is disappointing. This may be partly because of accessory renal arteries too small for denervation, causing incomplete ablation.
Pim Gal, Arif Elvan, Jan A. Staessen
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The future of renal denervation
Autonomic Neuroscience, 2017The rationale for the renal denervation treatment of severe, drug-resistant essential hypertension remains valid, but the field is now at a procedural watershed. With the commonly flawed procedures of the past, most notably in the Symplicity HTN-3 trial, which typically directed ablating energy into the proximal renal arteries, coupled with the absence
Murray, Esler, Ling, Guo
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Renal Denervation for Hypertension
Current Problems in Cardiology, 2014Hypertension is the leading cause of mortality worldwide. Effective therapies are needed for resistant hypertension, a common condition characterized by inadequate blood pressure control despite 3 or more medications, which is associated with increased cardiovascular mortality.
Mackram F, Eleid +2 more
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Renal denervation for hypertension
Nature Reviews CardiologyInnovative therapies for hypertension are desperately needed given the rising prevalence and falling rates of control of hypertension despite an abundance of available medical therapies. Procedural interventions lower blood pressure without depending on adherence to medications, and endovascular renal denervation (RDN) is the interventional procedure ...
Naomi D. L. Fisher, Ajay J. Kirtane
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Renal denervation in multiple renal arteries
European Journal of Clinical Investigation, 2014AbstractBackgroundIn most previous studies investigating efficacy of renal denervation (RDN), patients with multiple renal arteries are generally excluded from treatment. This study was designed to determine the prevalence of multiple renal arteries in patients referred for RDN, to propose a classification for anatomical eligibility and to investigate ...
Willemien L, Verloop +7 more
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Renal Sympathetic Denervation and Renal Physiology
Current Clinical Pharmacology, 2013The sympathetic nervous system has a profound effect on the kidney's ability to regulate blood pressure and, vice versa, the kidney has an important effect on the overall sympathetic tone. As a result, renal sympathetic nerves are crucial for initiation and the maintenance of systemic hypertension.
Rigas G, Kalaitzidis +2 more
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2022
Abstract Renal denervation represents an interventional technique aimed at disrupting both efferent and afferent sympathetic signalling between the cardiovascular control centres in the brainstem and the kidneys to lower blood pressure. Renal neural signalling is important for renin–angiotensin–aldosterone system activation, among others,
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Abstract Renal denervation represents an interventional technique aimed at disrupting both efferent and afferent sympathetic signalling between the cardiovascular control centres in the brainstem and the kidneys to lower blood pressure. Renal neural signalling is important for renin–angiotensin–aldosterone system activation, among others,
openaire +1 more source