Results 221 to 230 of about 878,591 (299)

Harnessing the Folding of Antitumor Peptides for Controlled Carrier‐Free Drug Delivery

Small, EarlyView.
A disulfide‐bridged stapled p53 α‐helix co‐assembled with doxorubicin into protease‐resistant nanocomplexes. Reductive intracellular conditions induced helix refolding and nanostructure disassembly, which enabled the coordinated release of the chemotherapeutic agent and anticancer peptide.
Jae Yun Lee, Moo Chang Park, Sung Chan Choi, Jieun Kim, Joo‐young Kim, Jiah Lee, Hyun Jin Kim, Kyobum Kim, Yongju Kim, Woo‐jin Jeong   +9 more
wiley   +1 more source

Type of dialysis may influence the prognostic value of myocardial perfusion imaging in end stage renal disease: an observational [¹³N]NH₃ PET/CT study. [PDF]

EJNMMI Res
Wenning C, Gosmann TM, Vrachimis A, Schäfers MA, Reuter S.   +4 more
europepmc   +1 more source

Endocytosis‐independent cytosolic entry of messenger RNA via fluorous bilayer zippering attenuating Toll‐like receptor signaling and enables ischemic tissue salvage

Smart Molecules, EarlyView.
The present study establishes a paradigm shift in synthetic mRNA delivery through the convergence of three orthogonal chemistries—perfluoro‐acylation, bio‐orthogonal click cross‐linking, and disulfide reduction—within a single, modular polymer architecture. Abstract A fundamental constraint of conventional messenger RNA (mRNA) delivery systems is their
Yue Wang, Haitao Xie, Guoqing Xiang, Yanhua Li, Changgui Tong, Hongyan Cui, Qixian Chen, Haidong Li, Yan Zhao   +8 more
wiley   +1 more source

Microplastics and the Kidney: A Narrative Review of Human Evidence, Molecular Mechanisms of Cell Injury, and Future Directions. [PDF]

Int J Mol Sci
La Porta E, Gentile M, Quaglia M, Ducoli S, Massardo S, Verzola D, Mancianti N, Esposito P.   +7 more
europepmc   +1 more source

Boron‐embedded multifunctional nanoplatform toward potential combined boron neutron capture therapy and immunomodulation in glioma

Smart Molecules, EarlyView.
A brain‐targeting multifunctional nanoplatform (DM&Ce6@COF‐Ang) was engineered by employing boron‐enriched APTES‐COF‐1 as both the therapeutic boron agent and the nanocarrier co‐delivery of DMXAA and Ce6. This nanoplatform achieved synergistic tumor‐specific boron delivery, real‐time pharmacokinetic monitoring, and immunomodulation.
Yiming Liu, Xuejian Wang, Bangjian Li, Kun Shao, Jianlong Su, Yang Wang, Lin Cheng, Zhihao Wu, JinRong Li, Guanyi Zhang, Xu Wang, Yuxuan Zhang, Yuanhao Liu, Guangzhe Li   +13 more
wiley   +1 more source

A Small Dose With Large Movements: Suspected Gabapentin-Associated Mixed Hyperkinetic Movement Disorder in End-Stage Renal Disease: A Case Report. [PDF]

Cureus
Memari K, Prado Escobar D, Rodriguez SA, Gallo E, Manuel J, Cohen P, Williams S, Lazo LP.   +7 more
europepmc   +1 more source

Effect of Glutathione S‐Transferase and Metallothionein Polymorphisms on Mercury Levels and End‐Stage Renal Disease (ESRD) in Colombian Patients

Environmental Toxicology, EarlyView.
ABSTRACT Epidemiological studies have demonstrated a link between chronic kidney disease (CKD) and environmental mercury (Hg) exposure. Colombia has a well‐documented history of artisanal and small‐scale gold mining, where Hg exposure affects miners and nearby riverside and urban populations. This study aimed to evaluate the effects of polymorphisms in
Diana M. Narváez, Juliana Lago, Carlos Trillos, Marcela Varona, Leonardo Briceño, Ruth Marien Palma, Sonia M. Díaz, Gilma Hernández, Eliana M. Téllez, Juan Sebastián Aguilar, Daniela Castellanos, Xavier Martínez, Estefanía Zapata, Alix Rocio Barrios, Ignacio Villanueva, Michael R. Fonseca, Helena Groot   +16 more
wiley   +1 more source

Anchored but not safe: Rare but serious mechanical complications from peritoneal dialysis catheter suture fixation

UroPrecision, EarlyView.
Abstract Background Peritoneal dialysis (PD) catheter fixation techniques are frequently employed to minimize migration and optimize dialysate flow. While mechanical complications of PD catheters are well recognized, adverse events directly attributable to anchoring sutures are rarely described. We report two patients with end‐stage renal failure (ESRF)
Joseph Cai Sheng Wong, Justine Zinwen Chan, Candice Lee, Kaashi Amar Rai, Jeffrey J. Leow, Zhenbang Liu   +5 more
wiley   +1 more source

Prognostic value of contrast‐enhanced ultrasound in dogs with acute renal injury treated with haemodialysis

Veterinary Record, Volume 196, Issue 6, 15/22 March 2025.
Abstract Background It is clinically relevant to predict outcomes in dogs with acute kidney injury (AKI) treated with haemodialysis. The aim of this study was to evaluate the prognostic value of contrast‐enhanced ultrasound (CEUS) and its role in discriminating between AKI and acute impairment associated with chronic kidney disease (AKI/CKD).
Caterina Puccinelli, Ilaria Lippi, Tina Pelligra, Simonetta Citi   +3 more
wiley   +1 more source

Short‐Term Clinical Outcomes and Complication Timing in Patients With Postoperative Delirium After Major Emergency Abdominal Surgery: A Prospective Cohort Study

World Journal of Surgery, EarlyView.
Postoperative delirium is linked to increased morbidity, mortality, and prolonged hospitalization; however, its short‐term consequences after major emergency abdominal surgery remain insufficiently studied. This prospective cohort study included 752 patients undergoing major emergency abdominal surgery at Copenhagen University Hospital, Herlev, from ...
Astrid Warmbier Jensen, Julie Jensen, Lasse Rehné Jensen, Michael E. Benros, Dunja Kokotovic, Jakob Burcharth   +5 more
wiley   +1 more source