Results 41 to 50 of about 8,290 (174)

Enhancing SDT Efficacy of Doxorubicin‐Loaded Sonosensitizer Micelles to Overcome Resistance of Cancer Therapy by Optimizing Acoustic Parameters

Aggregate, EarlyView.
The study reveals that optimizing various parameters of sonodynamic therapy (SDT), including the functional characteristics of sonosensitizers and the optimization of acoustic parameters, can significantly enhance SDT therapeutic efficacy. When combined with chemotherapy, this approach effectively overcomes tumor resistance and induces antitumor immune
Zhuoran Gong, Deshang Hou, Yunxue Xu, Mengxuan Wang, Shiyin Lin, Yingjuan Zheng, Zhifei Dai   +6 more
wiley   +1 more source

An evaluation of U-Net in Renal Structure Segmentation [PDF]

arXiv, 2022
Renal structure segmentation from computed tomography angiography~(CTA) is essential for many computer-assisted renal cancer treatment applications. Kidney PArsing~(KiPA 2022) Challenge aims to build a fine-grained multi-structure dataset and improve the segmentation of multiple renal structures.
arxiv  

Evaluating Renal Disease in Pediatric‐Onset Antineutrophil Cytoplasmic Antibody–Associated Vasculitis: Disease Course, Outcomes, and Predictors of Outcome

Arthritis &Rheumatology, EarlyView.
Objective We aimed to study the disease course, outcomes, and predictors of outcome in pediatric‐onset antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV) affecting the kidneys. Methods Patients eligible for this study had a diagnosis of granulomatosis with polyangiitis (GPA), microscopic polyangiitis, or ANCA‐positive pauci‐immune ...
Kirandeep K. Toor, Audrea Chen, David A. Cabral, Cherry Mammen, Else S. Bosman, Ye Shen, Jeffrey N. Bone, Damien Noone, Eslam Al‐Abadi, Susanne Benseler, Roberta Berard, Marek Bohm, Sirirat Charuvanij, Kathryn Cook, Paul Dancey, Samundeeswari Deepak, Ciaran Duffy, Barbara Eberhard, Melissa Elder, Dirk Foell, Dana Gerstbacher, Merav Heshin‐Bekenstein, Adam Huber, Karen E. James, Susan Kim, Marisa Klein‐Gitelman, Neil Martin, Flora McErlane, L. Nandini Moorthy, Charlotte Myrup, Phil Riley, Susan Shenoi, Vidya Sivaraman, Tamara Tanner, Stacey Tarvin, Linda Wagner‐Weiner, Rae S. M. Yeung, Kelly L. Brown, Kimberly A. Morishita, on behalf of the PedVas Investigators Network   +39 more
wiley   +1 more source

Probability of Target Attainment Analyses to Inform Ceftolozane/Tazobactam Dosing Regimens for Patients With Hospital‐Acquired or Ventilator‐Associated Bacterial Pneumonia and End‐Stage Renal Disease Receiving Intermittent Hemodialysis

The Journal of Clinical Pharmacology, Volume 63, Issue 2, Page 166-171, February 2023., 2023
Abstract ASPECT‐NP, a phase 3 trial of ceftolozane/tazobactam in hospital‐acquired/ventilator‐associated bacterial pneumonia (HABP/VABP), excluded patients with end‐stage renal disease (ESRD). A modeling/simulation approach was undertaken to inform optimal dosing in this population, using previously developed ceftolozane and tazobactam population ...
Hwa‐Ping Feng, Yogesh T. Patel, Zufei Zhang, Jill Fiedler‐Kelly, Christopher J. Bruno, Elizabeth G. Rhee, Carisa De Anda, Wei Gao   +7 more
wiley   +1 more source

Autologous Nonmyeloablative Hematopoietic Stem Cell Transplantation for Diffuse Cutaneous Systemic Sclerosis: Identifying Disease Risk Factors for Toxicity and Long‐Term Outcomes in a Prospective, Single‐Arm Trial

Arthritis &Rheumatology, EarlyView.
Objective Two randomized trials for patients with diffuse systemic sclerosis (SSc) demonstrated an overall survival (OS) and event‐free survival (EFS) advantage of autologous hematopoietic stem cell transplantation (AHSCT) using CD34+ selected peripheral blood stem cells (PBSCs) compared with monthly cyclophosphamide (CY).
George E. Georges, Dinesh Khanna, Mark H. Wener, Matthew G. Mei, Maureen D. Mayes, Robert W. Simms, Vaishali Sanchorawala, Chitra Hosing, Suzanne Kafaja, Attaphol Pawarode, Leona A. Holmberg, Jason Kolfenbach, Daniel E. Furst, Keith M. Sullivan, Suiyuan Huang, Ted Gooley, Richard A. Nash   +16 more
wiley   +1 more source

Maribavir Pharmacokinetics and Safety in Participants With Moderate Hepatic Impairment: A Phase 1, Open‐Label, Single‐Dose, Parallel Group Study

The Journal of Clinical Pharmacology, Volume 63, Issue 2, Page 250-258, February 2023., 2023
Abstract Maribavir, an orally bioavailable antiviral, has shown superior activity against posttransplant cytomegalovirus infection compared with conventional antivirals. It is primarily metabolized in the liver. This open‐label, single‐center study evaluated the effect of hepatic impairment on the pharmacokinetics of maribavir in nontransplant ...
Ivy Song, Grace Chen, Jingyang Wu, Katarina Ilic   +3 more
wiley   +1 more source

The effect of severe renal impairment on the pharmacokinetics, safety and tolerability of balcinrenone

British Journal of Clinical Pharmacology, EarlyView.
Aims The aim of this phase 1 trial was to assess the pharmacokinetics, safety and tolerability of balcinrenone (previously AZD9977) in participants with severe renal impairment vs. those with normal renal function. Methods Participants with severe renal impairment (estimated glomerular filtration rate [eGFR] < 30 mL/min/1.73 m2) not on dialysis were ...
Chandrali S. Bhattacharya, Hans Ericsson, Susanne Johansson, Joanna Parkinson, Simina M. Boca, Ye Yang, Maria Heijer, Greggory Housler, Maria Leonsson‐Zachrisson, Judith Hartleib‐Geschwindner, Patricia Ely Pizzato   +10 more
wiley   +1 more source

The tacrolimus concentration‐to‐dose ratio is associated with kidney function in heart transplant recipients

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Heart transplantation (HT) is frequently complicated by chronic kidney disease, of which tacrolimus‐related nephrotoxicity is an important cause. In kidney and liver transplant recipients, fast tacrolimus metabolism (defined as a low concentration‐to‐dose [C0/D] ratio), negatively affects kidney function.
Maaike R. Schagen, Teun B. Petersen, Boris C. A. Seijkens, Jasper J. Brugts, Kadir Caliskan, Alina A. Constantinescu, Brenda C. M. de Winter, Isabella Kardys, Dennis A. Hesselink, Olivier Manintveld   +9 more
wiley   +1 more source

First‐time cefuroxime target tissue concentrations in long‐lasting spine surgery: Continuous evaluation after repeated weight‐dosed administrations

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Antimicrobial prophylaxis is central in preventing postoperative spine infections, yet knowledge on clinical target spine tissue concentrations remain limited. Current dosing regimens often involve fixed doses based on empirical knowledge, surrogate measures, non‐clinical evidence and methodology of variying quality.
Magnus Andreas Hvistendahl, Mats Bue, Pelle Hanberg, Sara Kousgaard Tøstesen, Sofus Vittrup, Maiken Stilling, Kristian Høy   +6 more
wiley   +1 more source

The impact of race/ethnicity on pancreaticoduodenectomy outcomes for pancreatic cancer

Journal of Surgical Oncology, Volume 127, Issue 1, Page 99-108, January 2023., 2023
Abstract Purpose To investigate the impact of race/ethnicity on surgical outcomes following pancreaticoduodenectomy for pancreatic cancer. Methods A retrospective review of patients undergoing pancreaticoduodenectomy for adenocarcinoma in the National Surgical Quality Improvement Program (NSQIP) database from 2014 to 2019.
Yahya Alwatari, Catalina M. Mosquera, Jad Khoraki, Salem Rustom, Natalie Wall, Athanasios E. Sevdalis, Weston Stover, Jose G. Trevino, Brian Kaplan   +8 more
wiley   +1 more source