Results 41 to 50 of about 299,030 (338)

Early onset of graft glomerulopathy in a patient with post-transplant diabetes mellitus after renal transplantation: a case report

BMC Nephrology, 2018
Background Post-transplant diabetes mellitus (PTDM) is an emerging problem in kidney transplantation, representing an important risk factor for kidney function loss.
Marilena Gregorini, Vincenzo Sepe, Francesca Eleonora Pattonieri, Anna Allesina, Teresa Rampino   +4 more
doaj   +1 more source

Pharmacokinetics, Pharmacodynamics, and Safety of Subcutaneous Belimumab in Pediatric Patients with Systemic Lupus Erythematosus: A Multicenter, Open‐Label Trial

Arthritis Care &Research, Accepted Article.
Objective This study aimed to characterize the pharmacokinetics, pharmacodynamics, safety, and exploratory efficacy of subcutaneous belimumab in pediatric patients with active systemic lupus erythematosus (SLE) receiving standard therapy. Methods This single‐arm, multicenter, open‐label trial (GSK study 200908; NCT04179032) used three‐weight‐band ...
Hermine I. Brunner, Jordi Antón, Inmaculada Calvo‐Penadés, Richard Dimelow, Gerd Horneff, Sylvia Kamphuis, Rebecca Marino, Andre van Maurik, Kirsten Minden, Masaaki Mori, Josephine Ocran‐Appiah, Christel Wilkinson, Yuichi Yamasaki, Deepak Assudani, for the Pediatric Rheumatology Collaborative Study Group (PRCSG) and Paediatric Rheumatology International Trials Organisation (PRINTO) network investigators   +14 more
wiley   +1 more source

PRELIVE: A Framework for Predicting Lipid Nanoparticles In Vivo Efficacy and Reducing Reliance on Animal Testing

Advanced Functional Materials, EarlyView.
PREdicting LNP In Vivo Efficacy (PRELIVE) framework enables the prediction of lipid nanoparticle (LNPs) organ‐specific delivery through dual modeling approaches. Composition‐based models using formulation parameters and protein corona‐based models using biological fingerprints both achieve high predictive accuracy across multiple organs.
Belal I. Hanafy, Chuan‐En Lu, Kai Liu, Audrey Gallud   +3 more
wiley   +1 more source

The SF36 as an outcome measure of services for end stage renal failure [PDF]

, 1998
OBJECTIVE: —To evaluate the use of the short form 36 (SF36) as a measure of health related quality of life of patients with end stage renal failure, document the results, and investigate factors, including mode of treatment, which may influence it.
Brazier, J.E., Brown, C.B., Edwards, L., Payne, J.N., Walters, S., Wight, J.P.   +5 more
core   +2 more sources

Development of a Synthetic 3D Platform for Compartmentalized Kidney In Vitro Disease Modeling

Advanced Healthcare Materials, EarlyView.
A fully synthetic, compartmentalized 3D kidney disease model is introduced. The kidney model combines a PEG‐based hydrogel matrix with anisotropic, enzymatically degradable rod‐shaped microgels to spatially arrange a triple co‐culture of key renal epithelial, endothelial, and fibroblast cells.
Ninon Möhl, Daphne Bouwens, Johanna Abele, Aline Hans, Tanja Topic, Daniel Günther, Jitske Jansen, Rafael Kramann, Laura De Laporte   +8 more
wiley   +1 more source

Multivalent Protein Nanorings for Broad and Potent SARS‐CoV‐2 Neutralization

Advanced Healthcare Materials, EarlyView.
A protein‐only, modular multivalent nanoscaffold displaying 20 anchor points, decorated with two different binders (10 of each), targeting the SARS‐CoV‐2 receptor‐binding domain is presented. The construct self‐assembles into stable, biocompatible, homogeneous nanoparticles, exhibit synergistic binding with fM IC50 values. It also detects spike at 9 ng 
Molood Behbahanipour, Carla Goldin, Cecilia Arahi Prato, Ana Luz Paletta, Oriol Bárcenas, Susanna Navarro, Jordi Pujols, Daniel H. Murgida, María Virginia Tribulatti, Sebastián Esperante, Damian Alvarez‐Paggi, Salvador Ventura   +11 more
wiley   +1 more source

Annual dialysis data report 2021, Japanese Society for Dialysis Therapy (JSDT) renal data registry

Renal Replacement Therapy
The annual survey of the Japanese Society for Dialysis Therapy (JSDT) Renal Data Registry (JRDR) at the end of 2021 was conducted at 4508 facilities, of which 4454 facilities (98.8%) returned the facility questionnaire and 4251 (94.3%) returned the ...
Norio Hanafusa, Masanori Abe, Nobuhiko Joki, Junichi Hoshino, Atsushi Wada, Kan Kikuchi, Shunsuke Goto, Tetsuya Ogawa, Eiichiro Kanda, Masatomo Taniguchi, Shigeru Nakai, Toshihide Naganuma, Takeshi Hasegawa, Kenichiro Miura, Yoshiaki Takemoto, on behalf of Japanese Society for Dialysis Therapy Renal Data Registry Committee   +15 more
doaj   +1 more source

Narrative Review of Incremental Hemodialysis. [PDF]

, 2020
The prescription of hemodialysis (HD) in patients with incident end-stage kidney disease (ESKD) is fundamentally empirical. The abrupt transition from nondialysis chronic kidney disease (CKD) to thrice-weekly in-center HD of much the same dialysis ...
Garneata, Liliana, Kalantar-Zadeh, Kamyar, Moossavi, Shahriar, Murea, Mariana   +3 more
core  

Characterization of an Injectable Poly(vinyl alcohol)‐gelatin Hydrogel for Growth Factor Delivery in an Orthopedic Application

Advanced Healthcare Materials, EarlyView.
This work introduces photo‐crosslinkable tyraminated poly(vinyl alcohol)‐gelatin (PVA‐GT) hydrogels as tunable injectable platforms for tissue engineering and growth factor delivery applications. This schematic illustrates the two developed hydrogel formulations and the experimental workflow used to evaluate their physico‐chemical properties in vitro ...
Alessia Longoni, Gretel S. Major, Sam Arnold, Samuel Tomkins, Eugenia Spessot, Scott Loeffler, Kieran Lau, Richard Tan, Jessica Harte, Roslyn Kemp, Tess Reynolds, Jelena Rnjak‐Kovacina, Gary J. Hooper, Tim B. F. Woodfield, David C. Kieser, Khoon S. Lim   +15 more
wiley   +1 more source

Annual dialysis data report 2022, Japanese Society for Dialysis Therapy (JSDT) Renal Data Registry

Renal Replacement Therapy
The annual survey of the Japanese Society for Dialysis Therapy Renal Data Registry (JRDR) was sent to 4521 dialysis facilities at the end of 2022, among which 4464 facilities (98.7%) responded to the facility survey, and 4276 facilities (94.6%) responded
Norio Hanafusa, Masanori Abe, Nobuhiko Joki, Junichi Hoshino, Masatomo Taniguchi, Kan Kikuchi, Takeshi Hasegawa, Shunsuke Goto, Tetsuya Ogawa, Eiichiro Kanda, Shigeru Nakai, Toshihide Naganuma, Kenichiro Miura, Atsushi Wada, Yoshiaki Takemoto   +14 more
doaj   +1 more source