Results 71 to 80 of about 878,591 (299)

Natural Product Toosendanin Suppresses the Malignant Development of Skin Melanoma by Targeting BNC2 for Degradation

Advanced Science, EarlyView.
BNC2 exhibits context‐dependent opposing functions across multiple cancer types. This study reveals BNC2 as an oncogenic driver of melanoma proliferation and metastasis through transcriptional activation of PIK3CA. The natural compound TSN simultaneously degrades BNC2 and its oncogenic partner SMAD3 via CRBN‐dependent ubiquitination.
Hui Dai, Xin Mei Zhang, Jing Cheng Zhang, Xu Ting Deng, Qiao Liu, Mustafa Hussein Ali, Fang Zhou Yin, Wu Yin   +7 more
wiley   +1 more source

Current dialyzer classification in Japan and mortality risk in patients undergoing hemodialysis

Scientific Reports
Dialyzers are classified into five types based on their β2-microglobulin clearance rate and albumin sieving coefficient: Ia, Ib, IIa, and IIb. In addition, a new classification system introduced a type S dialyzer.
Masanori Abe, Kan Kikuchi, Atsushi Wada, Shigeru Nakai, Eiichiro Kanda, Norio Hanafusa   +5 more
doaj   +1 more source

A comparison of the epidemiology of kidney replacement therapy between Europe and the United States: 2021 data of the ERA Registry and the USRDS [PDF]

[EN] Background This paper compares the most recent data on the incidence and prevalence of kidney replacement therapy (KRT), kidney transplantation rates, and mortality on KRT from Europe to those from the United States (US), including comparisons of ...
Mingo, Pablo Ucio, Rodríguez Arévalo, Olga Lucía, Astley, Megan E., Slon Roblero, Maria F., Boenink, Rianne, Ruiz San Millán, Juan C., Ambühl, Patrice M., Skrunes, Rannveig, Boerstra, Brittany A., ten Dam, Marc A.G.J., Stel, Vianda S., Bell, Samira, Radunovic, Danilo, Resic, Halima, Aresté-Fosalba, Nuria   +14 more
core   +1 more source

Adjunctive treatment with moxonidine versus nitrendipine for hypertensive patients with advanced renal failure: a cost-effectiveness analysis [PDF]

, 2007
Littlewood KJ, Greiner W, Baum D, Zoellner Y. Adjunctive treatment with moxonidine versus nitrendipine for hypertensive patients with advanced renal failure: a cost-effectiveness analysis. BMC Nephrology.
Greiner, Wolfgang, Kavi J Littlewood, Littlewood, Kavi J., Zoellner, York, Baum Dominique, Baum, Dominique, Littlewood Kavi J, Greiner Wolfgang, York Zoellner, Zoellner York, Dominique Baum, Wolfgang Greiner   +11 more
core   +2 more sources

D4F‐Functionalized Ceria Nanozyme‐CasRx Platform Suppresses STING and Reprograms the Renal Immune Niche in Acute Kidney Injury

Advanced Science, EarlyView.
D4F‐functionalized ceria nanozyme–CasRx nanoparticles preferentially target renal macrophages through SR‐B1‐mediated uptake in ischemia–reperfusion injury. Ceria scavenges excessive ROS, while CasRx silences STING signaling, shifting macrophages toward a less inflammatory, pro‐resolving state and increasing the proportion of regulatory T cells.
Weibo Chen, Ming Li, Xuesheng Wang, Jiajia Sun, Ziyuan Zhang, Yongfeng Gong, Benkang Shi, Nengwang Yu, Yunuo Mao, Shengtian Zhao, Xiulin Zhang, Liqiang Guo   +11 more
wiley   +1 more source

A Dual‐Membrane Biomimetic Nanoplatform Enables Triple‐Modal Therapy Against SARS‐CoV‐2 Through Viral Decoy, Inflammation Neutralizing, and Intracellular RNAi

Advanced Science, EarlyView.
[A&T]MLN is a triple‐modal nanoplatform with siRNA‐loaded LN coated with hybrid ACE2/macrophage membrane. It blocks viral entry, neutralizes IL‐6/IL‐1β/TNF‐α, and delivers siRNA to suppress viral replication. In a murine lung injury model, it attenuates inflammation, offering a multi‐pronged strategy against SARS‐CoV‐2 variants and hyperinflammation ...
Hui Li, Bohan Zhang, Chao Shang, Yi Li, Te Zhao, Shengya Liu, Dan Liu, Junwei Che, Cuiling Zhang, Pinghui Wu, Wenjie Yang, Junjie Ding, Yuhua Ran, Yanan Zhai, Haihua Xiao, Jing Gao, Xiao Li, Chunsheng Gao, Lin Li, Zhiping Li   +19 more
wiley   +1 more source

Renal Dialysis Patient Dependency Classification Instrument: Phase 3- Validation study February 2017 [PDF]

, 2018
This report provides an analysis and evaluation of the Renal Dialysis Patient Dependency Classification (RDPDC) instrument. The RDPDC is a dependency classification tool designed specifically for use with renal dialysis out-patients.
Boilson, Andrew, Kane, Raphaela
core   +1 more source

Intelligent Programmable Membrane Nanosponge for Early Virus Blocking

Advanced Science, EarlyView.
A smart programmable nanosponge (ACNPs) displays high‐density viral receptors on its membrane and encapsulates fusion inhibitors to capture virions at the infection source through competitive binding and blocks their entry through protease inhibition for ultra‐early cascade interception. This modular, mucus‐penetrating platform shifts antiviral defence
Ze Chen, Zhuojun He, Huimin Guo, Min Shi, Ruijing Liang, Lanlan Liu, Yeneng Dai, Qi Zhao, Ke Liu, Yang Zhou, Yang Zhang, Jian Ren, Bin Ju, Quan Fang, Zhaozhen Li, Pengfei Zhao, Mingbin Zheng, Lintao Cai   +17 more
wiley   +1 more source

POS-786 PLASMAPHERESIS THERAPY IN KIDNEY TRANSPLANT PATIENTS: A SINGLE CENTER EXPERIENCE

Kidney International Reports, 2021
I. EL MEKNASSI, W. Sahtout, D. Zellama, A. Azzabi, N. Ben Aicha, S. Mrabet, A. Fradi, F. Sabri, S. Ben Amor, Y. Guedri, A. Achour   +10 more
doaj   +1 more source

Restoring Endothelial Mitochondrial Homeostasis With a Bioactive Nanoshield Promotes Vascular Regeneration on Cardiovascular Implants

Advanced Science, EarlyView.
A bioactive poly(citrate‐polyglycol‐procyanidin) (PCGP) nanoshield is developed for cardiovascular implants to restore endothelial mitochondrial homeostasis following vascular injury. By preserving mitochondrial integrity, re‐establishing metabolic balance, and activating PI3K/Akt/eNOS‐NO signaling, the PCGP interface promotes functional endothelial ...
Xiyu Liu, Wen Zhang, Lunxin Liu, Lan Gui, Yumei Qin, Xiaohui Yang, Longjian Zhang, Chaohua Wang, Jinpeng Hu, Gaoyang Guo, Qing Jiang, Jin Wang, Li Yang, Bo Zhang, Yunbing Wang   +14 more
wiley   +1 more source