Results 241 to 250 of about 987,918 (314)

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Impact of renal function on antidiabetic drug selection in Japan: A real-world analysis using the J-DREAMS database. [PDF]

J Diabetes Investig
Kubota M, Ohsugi M, Ueki K.
europepmc   +1 more source

Legumain Restrains Granuloma Formation by Inhibiting mTORC1/STAT1‐Mediated M1 Macrophage Polarization in Sarcoidosis

Advanced Science, EarlyView.
Legumain (LGMN) is upregulated in macrophages during sarcoid‑like granuloma formation. Macrophage‑derived LGMN binds to integrin αvβ3 and suppresses mTORC1/STAT1 signaling to restrain M1 macrophage polarization. Intratracheal delivery of lipid nanoparticles carrying Lgmn plasmid DNA (pDNA) elevates LGMN expression and effectively attenuates pulmonary ...
Mengyuan Liu, Yueyin Han, Bingbing Xie, Lili Zhu, Wenxiu Xu, Yinzhen Han, Yue Liao, Shuwei Gao, Dingyuan Jiang, Jing Geng, Zhen Li, Yinan Hu, Huaping Dai   +12 more
wiley   +1 more source

The Impact of BMI on Perioperative Urine Volume and Renal Function in Living Donor Kidney Transplantation. [PDF]

Cureus
Todaka M, Ando T, Fujinami H, Yamanaka N, Hata S, Inoue T, Shin T.   +6 more
europepmc   +1 more source

Severe Hyperkalemia Caused by Excessive Consumption of Dried Orange Juice in a Patient With Normal Renal Function. [PDF]

Cureus
Elshaikh O, Elkhider O, Sharma A.
europepmc   +1 more source

Renal function dynamics in COVID-19: exploring biomarker interactions with D-dimer and C-reactive proteins. [PDF]

Biosci Rep
Saha I, Sinha A, Kumar Sadhu A, Das RN, Ghosh S, Banerjee P, Banerjee O, Sarkar Biswas S, Mukherjee S, Pal PK.   +9 more
europepmc   +1 more source

Effect of antiretrovirals on renal function in people taking HIV pre-exposure prophylaxis. [PDF]

Rev Lat Am Enfermagem
Pontes-Pereira PS, Santana RC, Gir E, Reis RK.   +3 more
europepmc   +1 more source

Baicalin ameliorates podocyte injury and renal function impairment in idiopathic membranous nephropathy by inhibiting the AGE/RAGE signaling. [PDF]

Ren Fail
Lou C, Zhou Y, Feng B, Fan X, Xu X, Hu P, Wang X.   +6 more
europepmc   +1 more source