Results 281 to 290 of about 1,420,024 (339)

UCP2 Upregulates ACSL3 to Enhance Lipid Droplet Release from Acinar Cells and Modulates the Sirt1/Smad3 Pathway to Promote Macrophage‐to‐Myofibroblast Transition in Chronic Pancreatitis

Advanced Science, EarlyView.
These findings suggest that UCP2 promotes LD formation and release in acinar cells by upregulating ACSL3 expression. This alteration in the local lipid metabolic environment indirectly drives the MMT process. Additionally, UCP2 may regulate the acetylation of Smad3 through Sirt1, enhancing its nuclear activity and activating the TGF‐β/ Smad3 signaling ...
Kunpeng Wang, Lilong Zhang, Beiying Deng, Wanrong Jiang, Tianrui Kuang, Chen Chen, Kailiang Zhao, Qiao Shi, Jun He, Weixing Wang   +9 more
wiley   +1 more source

Changes in renal function after liver transplantation under FK 506 [PDF]

, 1991
Deballi, P, Fung, JJ, Jain, A, McCauley, J, Starzl, TE, Todo, S   +5 more
core  

Emodin Alleviates Sepsis‐Induced Multiorgan Damage by Inhibiting NETosis through Targeting Neutrophils BCL‐10

Advanced Science, EarlyView.
Emodin targets BCL‐10 to modulate the BCL‐10/MALT1 complex, thereby suppressing NF‐κB activation and significantly exerting multiorgan protective effects in sepsis. Abstract Sepsis is a life‐threatening condition caused by dysregulated host responses to infection, characterized by excessive inflammation and abnormal coagulation.
Xiaolong Xu, Yumeng Yan, Meiling Zheng, Mina Zhang, Tengfei Chen, Zhicheng Qu, Yinglu Bai, Shuwen Zhang, Chunming Zhao, Yifan Shi, Yan Lin, Ning Wang, Yunjing Bai, Yating Zhai, Zhaofang Bai, Wei Guo, Qingquan Liu   +16 more
wiley   +1 more source

SOX9-dependent fibrosis drives renal function in nephronophthisis. [PDF]

EMBO Mol Med
Patel MM, Gerakopoulos V, Lettenmaier B, Petsouki E, Zimmerman KA, Sayer JA, Tsiokas L.   +6 more
europepmc   +1 more source

Exploring Functionally Enhanced BLP‐Trained Macrophage Subpopulations in S. Aureus Infection: Underlying Mechanisms and Therapeutic Significance

Advanced Science, EarlyView.
BLP‐trained macrophages show augmented resistance to infection, but their mechanisms remain unclear. scRNA‐seq identified 13 BMDM subsets, with two novel anti‐inflammatory/antibacterial subpopulations (C5/C7) emerging post‐BLP training. BLP training activates NRF2, attenuates oxidative stress/ferroptosis, and boosts glycolysis/OXPHOS. Adoptive transfer
Yantong Wan, Yinghao Hong, Xiangjun Ji, Jing Xiang, Jinxi Liu, Lixin Liang, Meng Ren, Wenhan Chen, Tengfei Xu, Zhijie Li, Tieliu Shi, Yong Jiang, Huaping Liang, Jinghua Liu   +13 more
wiley   +1 more source

Renal function in diabetic retinopathy

Indian Journal of Ophthalmology, 1983
Khasgiwala S
doaj  

Effects of transcatheter tricuspid valve replacement on hepatic and renal function in severe TR. [PDF]

Int J Cardiol Heart Vasc
Li Z, Lin D, Miao J, Fan J, Lu F, Zhang X, Pan W, Zhou D, Ge J.   +8 more
europepmc   +1 more source

The role of serum uric acid in frailty among individuals with reduced renal function: a cross-sectional study base on CHARLS. [PDF]

Sci Rep
Wang Y, Zhang F, Chen Y, Deng Y, Zhong Y.   +4 more
europepmc   +1 more source