Results 281 to 290 of about 1,236,008 (363)

ISG15 Enhances the Activity of γ‐Glutamate Cysteine Ligase to Suppress Apoptosis in High Fat Diet‐Promoted Hepatocellular Carcinoma

open access: yesAdvanced Science, EarlyView.
Hepatocellular carcinoma (HCC) cells under high‐fat environment constrain harmful reactive oxygen species (ROS) by enhancing glutathione synthesis though upregulating interferon stimulated gene 15 (ISG15). In this process, upregulated high mobility group A1 (HMGA1) enhances ISG15 transcription, upregulated ISG15 subsequently noncovalently binds with ...
Xinran Liu   +21 more
wiley   +1 more source

CNPY2 Aggravates Renal Tubular Cell Ferroptosis in Diabetic Nephropathy by Regulating PERK/ATF4/CHAC1 Pathway and MAM Integrity

open access: yesAdvanced Science, EarlyView.
Canopy FGF signaling regulator 2 (CNPY2) which is contributed to ERS is upregulated in the renal tubules of patients with diabetic nephropathy (DN). Mechanistically, CNPY2 may regulate ferroptosis and MAM integrity in renal tubular epithelial cells through PERK/ATF4/CHAC1 pathway, thereby promoting the progression of DN.
Jingfang Chen   +9 more
wiley   +1 more source

The Development of a Predictive Model for Postoperative Renal Function in Living Kidney-Transplant Donors. [PDF]

open access: yesJ Clin Med
Tanaka R   +7 more
europepmc   +1 more source

Construction of a Biomimetic Tubular Scaffold Inspired by Sea Sponge Structure: Sponge‐Like Framework and Cell Guidance

open access: yesAdvanced Science, EarlyView.
Inspired by the structure of sea sponges, a unique method involving microfluidic coaxial spinning and in situ polymerization is designed. Biomimetic tubular scaffolds ae fabricated. Composed of specific materials such as oxidized bacterial cellulose, bacterial cellulose and polydopamine, these scaffolds have excellent mechanical stability and ...
Si Meng   +10 more
wiley   +1 more source

Improved Orthogonality in Naphthalimide/Cyanine Dyad Boosts Superoxide Generation: a Tumor‐Targeted Type‐I Photosensitizer for Photodynamic Therapy of Tumor by Inducing Ferroptosis

open access: yesAdvanced Science, EarlyView.
A tumor‐targeted, renal‐metabolized, and less O2‐dependent Type‐I photosensitizer is presented for photodynamic therapy of tumors. The formation of an intramolecular sandwich‐like π–π assembly ensures its rigid orthogonal geometry, thereby improving the superoxide (O2•−)‐generating ability, promoting the intracellular formation of hydroxy radical (HO•),
Guangxiao Yao   +3 more
wiley   +1 more source

PromarkerD Versus Standard of Care Biochemical Measures for Assessing Future Renal Function Decline in Type 2 Diabetes. [PDF]

open access: yesDiagnostics (Basel)
Peters KE   +5 more
europepmc   +1 more source

Inhalable Polymeric Nanoparticle Containing Triphenylphosphanium Bromide‐modified Sonosensitizer for Enhanced Therapy of Acute Bacterial Pneumonia

open access: yesAdvanced Science, EarlyView.
Bacterial pneumonia is the sixth leading cause of death. In this study, an inhalable polymeric nanoparticle NPFCPS‐P is developed, which under US stimulation showed high efficacy in the treatment of acute bacterial pneumonia. This nanoplatform would be much less prone to select bacterial resistance and represented a promising measure for antibiotics ...
Lin Wang   +6 more
wiley   +1 more source

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