Inducing ferroptosis is a promising strategy for combating tumor resistance. Upregulated PIP5K1A competes with NRF2 for KEAP1 binding, which decreases the ubiquitination degradation of NRF2 and promotes its nuclear translocation, thereby suppressing ferroptosis, and ultimately driving hepatocellular carcinoma (HCC) tumorigeneses and sorafenib ...
Mengzhou Guo+9 more
wiley +1 more source
Assessment of the renal function of patients with anorexia nervosa. [PDF]
Miyahara H+7 more
europepmc +1 more source
Multi‐Omics and ‐Organ Insights into Energy Metabolic Adaptations in Early Sepsis Onset
This study shows that patients at risk of sepsis have a distinct metabolite and lipid signature, including serine and aminoadipic acid, in their serum before clinical diagnosis. A mouse model of sepsis with a compatible serum signature reveals underlying metabolic changes, including mitochondrial adaptation, altered serine‐dependent purine metabolism ...
Lin‐Lin Xu+9 more
wiley +1 more source
The impact of warm ischemia time on short-term renal function after partial nephrectomy: a systematic review and meta-analysis. [PDF]
Li S+5 more
europepmc +1 more source
A Feedback Loop Between Fatty Acid Metabolism and Epigenetics in Clear Cell Renal Carcinoma
The current study has profiled the landscape of active enhancers in ccRCC and identified FABP5 as an oncogene. FABP5 is essential for the lipid droplet formation driven by HIFs and critical for H3K27ac and enhancer activity. The study has discovered the function of a feedback loop between epigenetics and lipid metabolism regulated by FABP5 in ccRCC ...
Zhou Ye+21 more
wiley +1 more source
Comparative assessment of the effects of dotinurad and febuxostat on the renal function in chronic kidney disease patients with hyperuricemia. [PDF]
Takata T+8 more
europepmc +1 more source
Renal Function and the Role of the Renin-Angiotensin-Aldosterone System (RAAS) in Normal Pregnancy and Pre-Eclampsia. [PDF]
Tsikouras P+16 more
europepmc +1 more source
Investigation of renal function in patients with long COVID in the Amazon region: a cross-sectional study. [PDF]
Assis GMCC+9 more
europepmc +1 more source
The impact of low-protein diet on residual renal function in dialysis patients: a systematic review and metaanalysis. [PDF]
Xie J, Liu X, Ling Y, Ge S, Yao Y.
europepmc +1 more source