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Addendum: Gabapentinoids and Renal Impairment
The Medical Letter on Drugs and Therapeutics, 2023A nephrologist and longtime reader of The Medical Letter wrote us to say that our recent article entitled Drugs for Anxiety Disorders should have said more about the need for dosage adjustment of gabapentin (Neurontin, and others) and pregabalin (Lyrica, and others) in patients with renal impairment.
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Nephrectomy in impaired renal function
Urology, 1974Abstract Nephrectomy was performed in 2 elderly patients despite a significant reduction in over-all renal function. Both exhibited a surprising degree of increase in function in the remaining kidney, as measured by serial clearance studies. These findings may be important in considering ablative renal surgery in patients with preexisting diminution ...
M, Schiff, B, Lytton, D J, Card
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Imaging patients with renal impairment
Abdominal Radiology, 2016Imaging with intravascular contrast media is generally considered safe, particularly in patients without renal failure. However, as renal function deteriorates, the potential risk of nonallergic-type adverse events increases. This presents a unique challenge, particularly when the use of intravenous contrast media is deemed essential for diagnostic ...
Mahan, Mathur, Jeffrey C, Weinreb
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Cimetidine and Impaired Renal Function
Annals of Internal Medicine, 1979Excerpt To the editor: Even though there is now extensive experience with the use of Cimetidine, its use in patients with renal failure is still limited.
G D, Luk, W J, Luk, T R, Hendrix
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Renal impairment in hypophosphatasia
Archives de Pédiatrie, 2017Renal impairment in hypophosphatasia (HPP) has been described but remains poorly understood: hypercalciuria, nephrocalcinosis and sometimes even chronic kidney failure secondary to chronic hypercalcemia/hypercalciuria or exposure to toxic agents.
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Benoxaprofen kinetics in renal impairment
Clinical Pharmacology and Therapeutics, 1982To establish therapeutic guidelines, benoxaprofen kinetics were examined in 26 adult subjects with normal and decreased renal function. Mean peak plasma concentrations after a single 600-mg dose ranged from 58 to 72 mg/l, independent of renal function.
G R, Aronoff +4 more
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Biomarkers of impaired renal function
Current Opinion in HIV and AIDS, 2010Renal disease is increasingly common as life expectancy of HIV-infected persons continues to improve. Several biomarkers are available for monitoring renal function, although no consensus exists on how best to apply these tools in HIV infection. This review describes recent findings for the more common renal biomarkers.Although widely used in clinical ...
Post, Frank A +2 more
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Brivaracetam Disposition in Renal Impairment
The Journal of Clinical Pharmacology, 2012Brivaracetam is a novel high‐affinity SV2A ligand currently in clinical development for epilepsy. The objective was to characterize its disposition in patients with renal impairment. A single oral dose of 200 mg brivaracetam was administered to 9 patients with severe renal impairment not requiring dialysis (creatinine clearance <15 mL/ min, n = 6 ...
Maria Laura, Sargentini-Maier +4 more
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Postprocedural Renal Impairment
2016Contrast-induced acute kidney injury (CI-AKI) represents one of the most common complications in patients with renal impairment undergoing percutaneous coronary interventions. The optimal strategy to prevent CI-AKI remains uncertain. At present, the best approach is (1) to identify patients at risk using risk scores, (2) to minimize the amount of ...
Carlo Briguori, Michael Donahue
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Cefsulodin kinetics in renal impairment
Clinical Pharmacology and Therapeutics, 1982Cefsulodin kinetics were determined after a 500-mg dose to normal subjects and patients with varying degrees of renal insufficiency, including those requiring hemodialysis. Elimination kinetics were described by a two-compartment model. Steady-state volume of distribution was 0.26 l/kg regardless of renal function. When glomerular filtration rate (GFR)
T P, Gibson +3 more
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